PRIMA-1;NSC-281668;2,2-dimethylolquinuclidin-3-one;PRIMA-1 - CAS 5608-24-2 - Calbiochem;2-Bis(hydroxymethyl)-3-quinuclidinone;2,2-Bis(hydroxymethyl)quinuclidin-3-one;2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE;P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS;7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one;2,2-BIS(HYDROXYMETHYL)-1-AZABICYCLO[2,2,2]OCTAN-3-ONE
PRIMA-1 is a reactivator of p53 and inducer of apoptosis.
Biologische Aktivit?t
Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.
PRIMA-1 Upstream-Materialien And Downstream Produkte