Octadecanedioic acid mono-tert-butyl ester
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- CAS-Nr.
- 843666-40-0
- Englisch Name:
- Octadecanedioic acid mono-tert-butyl ester
- Synonyma:
- 18-(tert-Butoxy)-18-oxooctadecanoic acid;Octadecanedioic acid mono(1,1-dimethylethyl) ester;Octadecanedioic acid 1-tert-butyl ester;Octadecanedioic acid mono-t-butyl ester;18-(tert-Butoxy)-18-oxostearic acid, tert-Butyl 17-carboxyheptadecanoate;Boc-C16-COOH;18-(tert-Butoxy);ButOOC-C16-COOH ;mono-t-Butyl stearate;-18-oxooctadecanoic acid
- CBNumber:
- CB81519446
- Summenformel:
- C22H42O4
- Molgewicht:
- 370.57
- MOL-Datei:
- 843666-40-0.mol
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Octadecanedioic acid mono-tert-butyl ester Eigenschaften
- Schmelzpunkt:
- 68 °C
- Siedepunkt:
- 470.7±18.0 °C(Predicted)
- Dichte
- 0.950±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.78±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C22H42O4/c1-22(2,3)26-21(25)19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20(23)24/h4-19H2,1-3H3,(H,23,24)
- InChIKey
- WDUQJXKBWRNMKI-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCCCCCCCCCCCCCCCC(O)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Octadecanedioic acid mono-tert-butyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Octadecanedioic acid mono-tert-butyl ester is a non-cleavable ADC linker or alkyl chain-based PROTAC linker for the synthesis of antibody-drug couplings (ADCs) and PROTACs.
Verwenden
18-(tert-Butoxy)-18-oxooctadecanoic Acid is a synthetic intermediate used in the preparation of semaglutide. It can be produced by the catalysis of 18-hydroxyoctadecanoic acid by ethyl bromoacetate in the presence of formamide and magnetic trifluoroacetic acid.
Application
18-(tert-Butoxy)-18-oxooctadecanoic acid) is a short linker featuring a carboxylic acid and a tert-butyl ester. Carboxylic acids can be reacted with alcohols or amines, while the tert-butyl ester can be deprotected and further connected to another molecule. It is a pharmaceutical intermediate ingredient used in the preparation of somatostatin. It also has catalytic activity.
Synthese
A suspension of octadecanedioic Acid (15 g, 47.7 mmol) in Toluene (191 ml) was brought to reflux in 3 neck 1 L round bottom flask. When all the Acid was in solution, 1,1 -di-tert-butoxy-N, N-dimethylmethanamine (22.87 ml, 95 mmol) was added dropwise over 30 minutes. The reaction mixture was heated under reflux overnight. The reaction was stopped after 20 total hours of heating. The reaction mixture was cooled to room temperature, resulting in solid precipitation. The mixture was filtered by vacuum filtration. The resulting white solid was suspended in 200 ml dichloromethane and stirred for 15 minutes. The remaining solids were removed via vacuum filtration. The collected solids were again suspended in dichloromethane and stirred for 15 minutes. After a second filtration, the combined filtrates were concentrated in vacuo, and the resulting white powder 18-(tert-Butoxy)-18-oxooctadecanoic Acid was dried undervacuum.
Octadecanedioic acid mono-tert-butyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Octadecanedioic acid mono-tert-butyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 371)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
SyncoZymes (Shanghai) Co., Ltd.,
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+86-021-68187180-811 +86-13681683526
|
lchen@syncozymes.com |
China |
188 |
58 |
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XIAMEN SINOPEG BIOTECH CO., LTD.
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+86-0592-7761068 +8617350879715
|
changaiwei@sinopeg.com |
China |
176 |
58 |
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Changsha Morning Shine Co., Ltd.
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+8613751227286
|
luohuichao@csmspharm.com |
China |
198 |
58 |
|
Suzhou Nordica Biopharma CO.,LTD
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+86-18136148818 +86-18567353071
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3537297702@qq.com |
China |
299 |
58 |
|
Wuhan senwayer century chemical Co.,Ltd
|
+undefined-27-86652399 +undefined13627115097
|
market02@senwayer.com |
China |
904 |
58 |
|
Hebei Zhuanglai Chemical Trading Co.,Ltd
|
+8613343047651
|
admin@zlchemi.com |
China |
3002 |
58 |
|
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
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+8615350851019
|
admin@86-ss.com |
China |
1001 |
58 |
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Alpha Biopharmaceuticals Co., Ltd
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+86-15542445688
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sales@alphabiopharm.com |
China |
992 |
58 |
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Capot Chemical Co.,Ltd.
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+86-（0）57185586718 +86-13336195806
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sales@capot.com |
China |
29791 |
60 |
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Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1803 |
55 |
843666-40-0()Verwandte Suche:
- OCTADECANEDIOIC ACID MONO-TERT-BUTYL ESTER
- 18-(tert-Butoxy)
- -18-oxooctadecanoic acid
- Octadecanedioic acid,1-(1,1-dimethylethyl) ester
- 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid
- tert-butyl 17-carboxyheptadecanoate
- mono-t-Butyl stearate
- tert-Butyl Hydrogen Octadecanedioate
- Mono-tert-butyl Octadecanedioate
- Boc-C16-COOH
- -18-oxooctadecanoic acid
- TIANFUCHEM--843666-40-0---C22H42O4
- 18-[(2-Methyl-2-propanyl)oxy]-18-oxooctadecanoic acid
- 18-(tert-Butoxy)-18-oxooctadecanoic acid
- 18-(tert-Butoxy)-18-oxostearic acid, tert-Butyl 17-carboxyheptadecanoate
- Octadecanedioic acid 1-tert-butyl ester
- Octadecanedioic acid mono(1,1-dimethylethyl) ester
- Octadecanedioic acid mono-t-butyl ester
- Octadecanedioic acid mono-tert‐butyl ester/ Semaglutide side chain
- 1-(1,1-Dimethylethyl) octadecanedioate
- Antibody-drug conjugates linkers,Boc-C-16-COOH,ADC Linkers,Inhibitor,Boc C16 COOH,BocC16COOH,inhibit,PROTAC Linkers
- Octadecanedioic acid, 1-(1,1-dimethylethyl) ester (ACI)
- cotadecanedioic acid mono-tert-butyl ester
- 18-(tert-Butoxy)-18-oxostearic acid
- ButOOC-C16-COOH
- 843666-40-0
- 843666-40-0
