3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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- CAS-Nr.
- 151266-23-8
- Englisch Name:
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Synonyma:
- 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;IbrutinibIntermediate6;7-Iodo-7-deaza-8-aza-adenine;4-AMINO-3-IODO-1H-PYRAZOLO[3;4-AMino-3-iodopyrazolo[3,4-d]pyridine;3-iodo-4-Aminopyrazolo[3,4-d]pyridine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
- CBNumber:
- CB8144555
- Summenformel:
- C5H4IN5
- Molgewicht:
- 261.02
- MOL-Datei:
- 151266-23-8.mol
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3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Eigenschaften
- Siedepunkt:
- 312.3±52.0 °C(Predicted)
- Dichte
- 2.92±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Aggregatzustand
- powder to crystal
- pka
- 10.50±0.20(Predicted)
- Farbe
- White to Light yellow to Light orange
- Sensitive
- Light Sensitive
- maximale Wellenl?nge (λmax)
- 282nm(lit.)
- InChI
- InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
- InChIKey
- HQAIUXZORKJOJY-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=C2C(I)=NNC2=N1
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Synthese
A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 359)Lieferanten
151266-23-8()Verwandte Suche:
- 3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
- 3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
- 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-
- 4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine
- 3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine
- 7-Iodo-7-deaza-8-aza-adenine
- 3-iodopyrazolo[3,4-d]pyriMidin-4-aMine
- 4-AMino-3-iodopyrazolo[3,4-d]pyridine
- 3-iodo-4-aMino-1H-pyrazolo[3,4-d]pyriMidine
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine >
- 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ISO 9001：2015 REACH
- 4-AMINO-3-IODO-1H-PYRAZOLO[3
- TIANFU-CHEM - 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- 3-iodo-4-Aminopyrazolo[3,4-d]pyridine
- 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine
- 3-Iodo-4-amino-1H-pyrazolo[3,4-d]pyrimidine, 7-Iodo-7-deaza-8-azaadenine
- 3-iodo-5H-pyrazolo[3,4-d]pyrimidin-4-amine
- 4-AMINO-3-iodo-1H-Pyrazolo[3,4-D]Pyrimidin
- 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- IbrutinibIntermediate6
- 151266-23-8
- Heterocycle-Pyridine series
- pharmacetical
