PELITINIB
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- CAS-Nr.
- 257933-82-7
- Englisch Name:
- PELITINIB
- Synonyma:
- Pelitinib(EKB-569);PELITINIB;WAY172569;WAY 172569;WAY-172569;WAY-EKB 569;Pelitinib, >=98%;EKB-569 Pelitinib;257933-82-7 PELITINIB;PELITINIB (EKB-569;WAY-EKB 569)
- CBNumber:
- CB81011748
- Summenformel:
- C24H23ClFN5O2
- Molgewicht:
- 467.92
- MOL-Datei:
- 257933-82-7.mol
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PELITINIB Eigenschaften
- Schmelzpunkt:
- 173-178°C
- Siedepunkt:
- 655.5±55.0 °C(Predicted)
- Dichte
- 1.34
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- Aggregatzustand
- powder
- pka
- 12.23±0.43(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2933.59.8000 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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PELITINIB Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC
50 = 39 nM). It inhibits HER2 with a much weaker potency (IC
50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC
50s = ~2 μM).
Chemische Eigenschaften
Off-White Solid
Verwenden
Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
PELITINIB Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PELITINIB Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 192)Lieferanten
- PELITINIB
- 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
- (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
- WAY-EKB 569
- (2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide
- (E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
- (2e)-n-(4-((3-chloro-4-fluorophenyl)aMino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(diMethylaMino)-2-butenaMide pelitinib
- N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-but·Namide
- EKB-569 Pelitinib
- Pelitinib (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
- Pelitinib, >=98%
- (E)-N-(4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-
- PELITINIB (EKB-569;WAY-EKB 569)
- EKB-569; WAY-EKB 569; EKB569; EKB 569
- 257933-82-7 PELITINIB
- Pelitinib(EKB-569)
- WAY 172569
- WAY172569
- WAY-172569
- 257933-82-7
- C24H23ClFN5O2
- C24H17D6ClFN5O2
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Tyrosine Kinase Inhibitors
- pyridine
- All Inhibitors
- API
- Aromatics
- Heterocycles
- Isotope Labelled Compounds
