Etifoxine
|
|
|
- CAS-Nr.
- 21715-46-8
- Englisch Name:
- Etifoxine
- Synonyma:
- 36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- CBNumber:
- CB7875113
- Summenformel:
- C17H17ClN2O
- Molgewicht:
- 300.78
- MOL-Datei:
- 21715-46-8.mol
|
Etifoxine Eigenschaften
- Schmelzpunkt:
- 90-92℃
- Siedepunkt:
- 421.2±55.0 °C(Predicted)
- Dichte
- 1.1716 (rough estimate)
- Dampfdruck
- 0-1Pa at 20-25℃
- Brechungsindex
- 1.5800 (estimate)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
- Aggregatzustand
- Solid:particulate/powder
- pka
- 4.89±0.40(Predicted)
- Farbe
- Light yellow to yellow
- LogP
- 4.09-4.52 at 21-25℃ and pH7
Etifoxine Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Circupon,Troponwerke,W. Germany
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
Etifoxine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Etifoxine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 74)Lieferanten
21715-46-8()Verwandte Suche:
- etafenoxine
- 36-801
- 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- Etifoxin
- HOE-36801
- HOE-36-801
- 2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine
- Etifoxine
- 4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-
- Etifoxine (HOE36801)
- 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine
- 21715-46-8
