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Docetaxel

Docetaxel Struktur
125354-16-7
CAS-Nr.
125354-16-7
Englisch Name:
Docetaxel
Synonyma:
CS-878;DOCETAXOL;Docetaxal;PNU 101383;10-Acetyltaxotere;MK-0431 phosphate;10-Acetyldocetaxel;Docetaxel impurity G;ACETYLDOCETAXEL, 10-;Paclitaxel Impurity 3
CBNumber:
CB7842087
Summenformel:
C45H55NO15
Molgewicht:
849.93
MOL-Datei:
125354-16-7.mol

Docetaxel Eigenschaften

Schmelzpunkt:
201-203 °C(Solv: methanol (67-56-1))
Siedepunkt:
901.4±65.0 °C(Predicted)
Dichte
1.36±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
11.20±0.46(Predicted)
Farbe
White to Off-White

Sicherheit

Docetaxel Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.

Allgemeine Beschreibung

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.

Docetaxel Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Docetaxel Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 203)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10310 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
+8615377521700
wangwendy93@gmail.com China 868 58

125354-16-7()Verwandte Suche:


  • 10-Acetyldocetaxel
  • 10-Acetyltaxotere
  • Docetaxal
  • PNU 101383
  • ACETYLDOCETAXEL, 10-(P)
  • Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
  • DOCETAXOL
  • N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
  • Docetaxel impurity G
  • Docetaxel Impurity 7(Docetaxel EP Impurity G)
  • Docetaxel EP Impurity G
  • CS-878
  • Paclitaxel Impurity 3
  • Docetaxel EP Impurity G (10-Acetyl Docetaxel)
  • Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,...
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate
  • Docetaxel,125354-16-7
  • MK-0431 phosphate
  • 5β,20-epoxy-1,7β-dihydroxy-9-oxotax-11-ene-2α,4,10β,13α-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (10-acetyldocetaxel).
  • Docetaxel EP Impurity G(Paclitaxel Impurity 3)
  • ACETYLDOCETAXEL, 10-
  • 125354-16-7
  • C45H55NO15
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