SIRTINOL
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- CAS-Nr.
- 410536-97-9
- Englisch Name:
- SIRTINOL
- Synonyma:
- SIRTINOL;SIRTINOL USP/EP/BP;SIR TWO INHIBITOR NAPHTHOL;Sirtinol - CAS 410536-97-9 - Calbiochem;2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide;2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE;2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide;2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide;(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide;2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
- CBNumber:
- CB7748565
- Summenformel:
- C26H22N2O2
- Molgewicht:
- 394.47
- MOL-Datei:
- 410536-97-9.mol
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SIRTINOL Eigenschaften
- Schmelzpunkt:
- 119-120℃
- Siedepunkt:
- 659.2±50.0 °C(Predicted)
- Dichte
- 1.16
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 30 mg/ml).
- Aggregatzustand
- Yellow solid
- pka
- 7.85±0.50(Predicted)
- Farbe
- Pale yellow
- Wasserl?slichkeit
- Soluble in water, DMSO and methanol
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
SIRTINOL Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Sirtinol is a known inhibitor of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5 and exhibits anticancer properties.
Allgemeine Beschreibung
A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC
50 = 48 μM, 131 μM and 58 μM for ySir2, hSIRT1 and hSIRT2, respectively). Reported to inhibit Sir2p transcriptional silencing activity
in vivo (IC
50 = 25 μM), and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p and human SIRT2
in vitro (IC
50 = 70 μM and 40 μM, respectively). A 10 mM (1 mg/254 μl) solution of Sirtinol (Cat. No.
566321) in DMSO is also available.
Biologische Aktivit?t
Cell-permeable, selective sirtuin deacetylase inhibitor (IC 50 values are 38, 68 and 131 μ M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro .
SIRTINOL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SIRTINOL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 126)Lieferanten
410536-97-9()Verwandte Suche:
- 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE
- SIRTINOL
- SIR TWO INHIBITOR NAPHTHOL
- (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide
- 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
- 2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
- {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol)
- Sirtinol - CAS 410536-97-9 - Calbiochem
- 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide
- N-(1-ethyl-1-cyclohexa-2,4-dienyl)-2-[(2-oxo-1-naphthalenylidene)methylamino]benzamide
- Benzamide, 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-
- Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
- SIRTINOL USP/EP/BP
- 2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide
- 410536-97-9
- C26H22N2O2
- DNA-RNA Transcription Regulators
- Gene Regulation and Expression
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Inhibitors
- Inhibitor
- Other Enzyme Inhibitors.
- Other enzyme inhibitors and activators
