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Exendin-4

Exendin-4 Struktur
141758-74-9
CAS-Nr.
141758-74-9
Englisch Name:
Exendin-4
Synonyma:
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2;H-HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;XENDIN-4;EXENDIN-4;Exendin-4 >=97%;Exendin-4 Exenatide;Exenatide (2.73 mg);Exenatide free base;Exendin-4 USP/EP/BP;Exenatide (Exendin-4)
CBNumber:
CB7738335
Summenformel:
C184H282N50O60S
Molgewicht:
4186.57188
MOL-Datei:
141758-74-9.mol

Exendin-4 Eigenschaften

RTECS-Nr.
VT9545000
storage temp. 
−20°C
L?slichkeit
≥145 mg/mL in DMSO; insoluble in EtOH; ≥52 mg/mL in H2O with gentle warming
Aggregatzustand
White to off-white solid.
Farbe
White to off-white
Wasserl?slichkeit
Soluble in water (1 mg/ml)
InChIKey
HTQBXNHDCUEHJF-AAPNSGCPNA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2933290000
Giftige Stoffe Daten 141758-74-9(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Exendin-4 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Exenatide is the first drug in a new class of anti-diabetics known as the incretin mimetics, and it is indicated as adjunctive therapy to improve glycemic control in patients with type 2 diabetes who are taking metformin, a sulfonylurea, or both, but have not achieved adequate glycemic control. Exenatide is a functional analog of the human incretin Glucagon-Like Peptide-1 (GLP-1). GLP-1 is naturally released from cells in the GI tract in response to food intake and acts on its receptor on b-cells to potentiate glucose-stimulated insulin secretion. Exenatide is a long-acting agonist at the GLP-1 receptor. It is a synthetic version of a 39-amino acid peptide found in the salivary secretions of the Gila monster lizard.also moderates peak serum glucagon levels during hyperglycemic periods following meals, but does not interfere with glucagon release in response to hypoglycemia. The dosing regimen for exenatide is 5 or 10 mg twice daily, administered as a subcutaneous injection within an hour before morning and evening meals. Following subcutaneous administration, peak plasma concentrations of exenatide are reached in 2.1 h, and the plasma pharmacokinetic profile is dose proportional. The most common adverse events reported with exenatide include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, and dyspepsia.

Beschreibung

Exendin-4 is a 39 amino acid polypeptide and incretin mimetic involved in the glucose-dependent enhancement of insulin secretion. It was first isolated from Gila monster saliva. It also promotes the reduction of hyperglycemia, glucose-dependent suppression of inappropriately high glucagon secretion, slowing of gastric emptying, and reduction of food intake, often with body weight reduction or blunting of weight gain. The synthetic form, Exenatide, is a glucagon-like peptide-1 (GLP-1) agonist approved for the treatment of diabetes mellitus type II, has a long half-life.

Verwenden

Exendin-4 has been used as incretin mimetics for the treatment in HepG2 cells to exclude the influence of auxiliary material. It has also been used as an r (GLP-1R) agonist to exclude interference from auxiliary material.

Definition

ChEBI: A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently indu es cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide.

Allgemeine Beschreibung

Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids. It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life. Exendin-4 was historically isolated from the venom of Gila monster lizard called Heloderma suspectum.

Exendin-4 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Exendin-4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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141758-74-9()Verwandte Suche:


  • EXENDIN-4
  • M.W. 4186.61 C184H282N50O60S
  • HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
  • Exenatide, AC 2993, Exendin A, ExendinA
  • Exendin-4 Exenatide
  • Exenatide (Exendin-4)
  • Exenatide free base
  • XENDIN-4
  • Exenatide (2.73 mg)
  • Exendin-4 >=97%
  • Exenatide?Acetate impurity
  • Exendin-4 USP/EP/BP
  • Exendin-4 acetate salt
  • ExenatideQ: What is Exenatide Q: What is the CAS Number of Exenatide Q: What is the storage condition of Exenatide Q: What are the applications of Exenatide
  • TIANFU-CHEM - Exendin-4
  • H-HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
  • HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
  • Tolperisone Impurity 8
  • 141758-74-9
  • C184H282N50O60S
  • C184H282N50O60S1
  • 418657
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Cytokines, Growth Factors and Hormones
  • Exendin
  • Hormones
  • Obesity Research
  • Peptide
  • Cytokines Growth Factors and Hormones (Obesity)
  • ExendinPeptides for Cell Biology
  • GLP-1 Receptor LigandsCell Signaling and Neuroscience
  • LizardObesity Research
  • Obesity Peptides
  • Other Obesity Research Products
  • Hormones
  • Obesity Research
  • Toxins and Venoms
  • Glucagon receptor and related
  • Peptide Receptors
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