成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Dimercaprol

2,3-Dimercapto-1-propanol Struktur
59-52-9
CAS-Nr.
59-52-9
Bezeichnung:
Dimercaprol
Englisch Name:
2,3-Dimercapto-1-propanol
Synonyma:
BAL;DIMERCAPROL;2,3-DIMERCAPTOPROPAN-1-OL;BACS;BAL1;Parp9;Panobal;Antoxol;Dimersol;usafme-1
CBNumber:
CB7684878
Summenformel:
C3H8OS2
Molgewicht:
124.22
MOL-Datei:
59-52-9.mol

Dimercaprol Eigenschaften

Schmelzpunkt:
77 °C
Siedepunkt:
120 °C15 mm Hg(lit.)
Dichte
1.239 g/mL at 25 °C(lit.)
Dampfdichte
4.3
Dampfdruck
7.4 hPa (100 °C)
Brechungsindex
n20/D 1.573(lit.)
Flammpunkt:
>230 °F
storage temp. 
Store at +2°C to +8°C.
L?slichkeit
87g/l (slow decomposition)
pka
9.00±0.25(Predicted)
Aggregatzustand
Liquid
Farbe
Clear colorless to slightly yellow
PH
5.0-6.5 (H2O, 20℃)(saturated solution)
Geruch (Odor)
pungent odor
Wasserl?slichkeit
87 g/L (25 ºC)
Sensitive 
Air Sensitive
Merck 
14,3209
BRN 
1732058
Stabilit?t:
Stable. Combustible. Incompatible with strong oxidizing agents, many metals.
CAS Datenbank
59-52-9(CAS DataBase Reference)
NIST chemische Informationen
Dimercaprol(59-52-9)
EPA chemische Informationen
2,3-Dimercaptopropanol (59-52-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 22-36/37/38-36/38
S-S?tze: 26-36-24/25-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS-Nr. UB2625000
8-9-13-23
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29309070
Giftige Stoffe Daten 59-52-9(Hazardous Substances Data)
Toxizit?t LD50 i.m. in rats: 86.7 mg/kg (Zvirblis, Ellin)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Dimercaprol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).

Beschreibung

Dimercaprol (INN) or British anti - Lewisite (abbreviated BAL), is a compound developed by British biochemists at Oxford University during World War II . It was developed secretly as an antidote for lewisite, the now - obsolete arsenic - based chemical warfare agent . Today, it is used medically in treatment of arsenic, mercury , gold, lead, antimony, and other toxic metal poisoning . In addition , it has in the past been used for the treatment of Wilson's disease, a genetic disorder in which the body tends to retain copper.

Chemische Eigenschaften

colourless oily liquid with a typically offensive mercaptan smell

Verwenden

2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.

Definition

ChEBI: A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been use clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administrati n is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating g netic disorder in which the body tends to retain copper, with resultant liver and brain injury.

Biologische Funktion

Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme's activity. Dimercaprol competes with the thiol groups for binding the metal ion, which is then excreted in the urine .
Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs. Other drawbacks include the need to administer it by painful intramuscular injection. Serious side effects include nephrotoxicity and hypertension.
Dimercaprol has been found to form stable chelates in vivo with many other toxic metals including inorganic mercury, antimony, bismuth, cadmium, chromium, cobalt, gold, and nickel. However, it is not necessarily the treatment of choice for toxicity to these metals. Dimercaprol has been used as an adjunct in the treatment of the acute encephalopathy of lead toxicity. It is a potentially toxic drug, and its use may be accompanied by multiple side effects. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided. It does, however, remove inorganic mercury from the kidneys; but is not useful in the treatment of alkylmercury or phenyl mercury toxicity. Dimercaprol also enhances the toxicity of selenium and tellurium, so it is not to be used to remove these elements from the body.

Allgemeine Beschreibung

Clear colorless viscous liquid with a pungent offensive odor of mercaptans. Used as a medicine and an antidote to the chemical warfare agent LEWISITE.

Air & Water Reaktionen

Moderately soluble in water with decomposition [Hawley].

Reaktivit?t anzeigen

2,3-Dimercapto-1-propanol forms highly stable chelates with a variety of metal ions. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Brandgefahr

2,3-Dimercapto-1-propanol is probably combustible.

Pharmazeutische Anwendungen

Dimercaprol (BAL) is a chelating agent used as an antidote for arsenic, antimony, bismuth, gold and mercury poisoning. It has the chemical name 2,3-dimercapto-1-propanol and is a clear, colourless or slightly yellow liquid.

Clinical Use

2,3-Dimercapto-1-propanol, BAL, or dithioglycerol is afoul-smelling, colorless liquid. It is soluble in water (1:20)and alcohol. It was developed by the British during WorldWar II as an antidote for “Lewisite,” hence the name Britishanti-Lewisite or BAL. Dimercaprol is effective topicallyand systematically as an antidote for poisoning caused byarsenic, antimony, mercury, gold, and lead. It can, therefore,also be used to treat arsenic and antimony toxicity associatedwith overdose or accidental ingestion of organoarsenicalsor organoantimonials.The antidotal properties of BAL are associated with theproperty of heavy metals to react with sulfhydryl (SH)groups in proteins (e.g., the enzyme pyruvate oxidase) andinterfere with their normal function. 1,2-Dithiol compoundssuch as BAL compete effectively with such proteins for themetal by reversibly forming metal ring compounds.These are relatively nontoxic, metabolically conjugated(as glucuronides), and rapidly excreted.BAL may be applied topically as an ointment or injectedintramuscularly as a 5% or 10% solution in peanut oil.

Sicherheitsprofil

Poison via ingestion, intramuscular, parenteral, intraperitoneal, and intravenous routes. Experimental teratogenic effects. Human systemic effects by intramuscular route: hemorrhage and dermatitis. Human blood and systemic skin effects by intramuscular route. It causes redness and swelling when applied locally to the skin, but does not produce blisters or ulcers. Intensely irritating to eyes and mucous membranes. Systemic symptoms are caused by injection. When heated to decomposition, it emits toxic fumes of SO,. Used as an antidote to arsenic, gold, and mercury poisoning.

Environmental Fate

BAL is believed to compete with tissue sulfhydryl groups and interferes with cellular respiration. It also competes with metallic cofactors of metabolic enzyme systems and increases capillary permeability. Metabolic degradation and excretion are essentially complete within 4 h. BAL not excreted as dimercaprol– metal complex is quickly metabolized by the liver and excreted as an inactive product in the urine. Because it is a lipophilic drug, it penetrates rapidly the intracellular spaces. The highest concentrations are found in the liver, kidneys, brain, and small intestine. Due to its lipophilic characteristic, the complexes formed with mercury and other metals may be redistributed into sensitive cells in the brain following dimercaprol treatment.

l?uterung methode

Precipitate BAL as the Hg mercaptide [see Bj.berg Chem Ber 75 13 1942], regenerate with H2S, and distil it under a vacuum [Rosenblatt & Jean Anal Chem 951 1955]. It is an antidote for heavy metal (As, Hg, Au etc) poisoning. [Beilstein 1 IV 2770.]

Dimercaprol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dimercaprol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 271)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18150 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871
sales@ansciepchem.com CHINA 4241 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58

59-52-9(Dimercaprol)Verwandte Suche:


  • 3-hydroxy-1,2-propanedithiol
  • 1,2-DITHIOGLYCEROL
  • 1,2-Dimercapto-3-propanol
  • 1,2-Dimercaptopropanol
  • 1,2-dithio-glycero
  • 1-Propanol, 2,3-dimercapto-
  • dimercaprolpropanol
  • Dimercaptol
  • Dimerkaprol
  • Dimersol
  • Dithioglycerol
  • Glycerol, 1,2-dithio-
  • Panobal
  • Sulfactin
  • USAF me-1
  • usafme-1
  • BRITISH ANTI-LEWISITE
  • DITHIOGLYCERINE
  • DITHIOPROPANOL
  • DICAPTOL
  • Dimercaptopropanol
  • 2,3-DIMERCAPTOPROPANOL
  • 2,3-DIMERCAPTO-1-PROPANOL
  • 2,3-Dimercaptol-1-propanol
  • 2,3-DIMERCAPTO-1-PROPANOL, FOR COMPLEXOM ETRY
  • 2,3-Dimercapto-1-Propanol,>97%
  • 2,3-Dimercaptopropanol,95%
  • 2,3-Dimercapto-1-propanol, 97.0-100.5%
  • 1-propanol,2,3-dimercapto-
  • 2,3-dimercapto-1-propano
  • 2,3-Disulfanyl-1-propanol
  • 2,3-dithio-1-propanol
  • 2,3-Dithiopropanol
  • 2,3-Mercaptopropan-1-ol
  • alpha,beta-Dithioglycerol
  • Antoxol
  • BAL in Oil
  • Dimercaprol propanol
  • 1,2-dithioglycerine
  • 1-Propanol, 2,3-dimercapto- (8CI, 9CI)
  • 2,3-Dithiopropan-1-ol
  • NSC 39515
  • NSC 4646
  • 2,3-Mercaptopropanol-1
  • BAL, British anti-Lewisite, Dimercaprol, Dithioglycerol
  • 2,3-Dimercapto-1-propanol ,98.5%
  • 2,3-Dimercapto-1-propanol,BAL, British anti-Lewisite, Dimercaprol, Dithioglycerol
  • 2,3-Dimercapto-1-pro
  • 2,3-disulfanylpropan-1-ol
  • 2,3-DiMercapto-1-propanol, 97.0-100.5% 25ML
  • Dimercaprol BAL
  • 2,3-DIMERCAPTO-1-PROPANOL FOR COMPLEXOME
  • 2,3-DiMercapto-1-propanol >=98% (iodoMetric)
  • 2,3-DiMercaptopropanol, Reagent
  • BA-CoA ligase
  • BACS
  • Bile acyl-CoA synthetase
  • ANTI-MOUSE PARP9 (N-TERM) antibody produced in rabbit
Copyright 2019 ? ChemicalBook. All rights reserved