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GLS1 Inhibitor

GLS1 Inhibitor Struktur
1832646-52-2
CAS-Nr.
1832646-52-2
Englisch Name:
GLS1 Inhibitor
Synonyma:
GLS1 Inhibitor,GLS-1 Inhibitor;4-thiadiazol-2-yl]-benzeneacetamide;αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1;ΑS-METHOXY-N-[5-[[(3R)-1-(3-PYRIDAZINYL)-3-PYRROLIDINYL]AMINO]-1;3;4-THIADIAZOL-2-YL]-BENZENEACETAMIDE;Benzeneacetamide, α-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-, (αS)-
CBNumber:
CB75582380
Summenformel:
C19H21N7O2S
Molgewicht:
411.48
MOL-Datei:
1832646-52-2.mol

GLS1 Inhibitor Eigenschaften

Dichte
1.425±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
Aggregatzustand
A crystalline solid
pka
7.42±0.50(Predicted)

Sicherheit

GLS1 Inhibitor Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.021 μM). It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cells in vitro (GI50 = 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

GLS1 Inhibitor Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GLS1 Inhibitor Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 7)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195
 sales@tybiochem.com China 6813 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
 customer_service@efebio.com China 11974 58
  • 4-thiadiazol-2-yl]-benzeneacetamide
  • αS-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1
  • ΑS-METHOXY-N-[5-[[(3R)-1-(3-PYRIDAZINYL)-3-PYRROLIDINYL]AMINO]-1;3;4-THIADIAZOL-2-YL]-BENZENEACETAMIDE
  • Benzeneacetamide, α-methoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-, (αS)-
  • GLS1 Inhibitor,GLS-1 Inhibitor
  • 1832646-52-2
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