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(4-Aminobutyl)guanidiniumsulfat

Agmatine sulfate  Struktur
2482-00-0
CAS-Nr.
2482-00-0
Bezeichnung:
(4-Aminobutyl)guanidiniumsulfat
Englisch Name:
Agmatine sulfate
Synonyma:
AGMATINE SULPHATE;2-(4-aminobutyl)guanidine,sulfuric acid;gmatine sulfate;agmatine sulfate salt;1-AMINO-4-GUANIDINOBUTANE SULFATE SALT;ARGAMINE;matine SuL;Agmatine SuL;Agmatine sulfat;AGMATINE SULFATE
CBNumber:
CB7421831
Summenformel:
C5H16N4O4S
Molgewicht:
228.27
MOL-Datei:
2482-00-0.mol

(4-Aminobutyl)guanidiniumsulfat Eigenschaften

Schmelzpunkt:
234-238 °C(lit.)
RTECS-Nr.
ME8413000
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
Farbe
white to off-white
Wasserl?slichkeit
Soluble in water, nearly insoluble in alcohol
Merck 
14,188
BRN 
3918807
InChI
InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChIKey
PTAYFGHRDOMJGC-UHFFFAOYSA-N
SMILES
C(CCCN)NC(N)=N.S(O)(O)(=O)=O
CAS Datenbank
2482-00-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
10
HS Code  29252900
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(4-Aminobutyl)guanidiniumsulfat Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.

Chemische Eigenschaften

White to off-white powder

Verwenden

Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects.

Biologische Aktivit?t

Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.

l?uterung methode

Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]

Einzelnachweise

Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.
Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine

(4-Aminobutyl)guanidiniumsulfat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(4-Aminobutyl)guanidiniumsulfat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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2482-00-0((4-Aminobutyl)guanidiniumsulfat)Verwandte Suche:


  • N-(4-AMINOBUTYL)GUANIDINE SULFATE
  • N-(4-Aminobutyl)guanidine sulfate salt
  • 1-AMINO-4-GUANIDINOBUTANE SULFATE
  • 1-AMINO-4-GUANIDOBUTANE SULFATE
  • 4-GUANIDINOBUTANE SULFATE
  • 4-GUANIDINO-BUTYLAMINE SULFATE
  • 4-GUANIDINO-BUTYLAMINE SULFATE SALT
  • (4-AMINOBUTYL)GUANIDINE SULFATE
  • (4-aminobutyl)guanidinium sulphate
  • AGMATINE SULFATE
  • ARGAMINE
  • ARGAMINE SULFATE
  • AGMATINESULFATE,POWDER
  • (4-Aminobutyl)guanidinium sulfate.
  • AGMATINE SULFATE PRACTICAL GRADE
  • AGMATINE SULFATE((4-AMINOBUTYL)GUANIDINE)
  • AGARICUSBLAZTIP.E
  • 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt
  • 1-(4-aMinobutyl)guanidine sulfate
  • Agmatine sulfate,99%
  • Agmatine sulfate,85+%
  • Agmatine sulfate,70%
  • ArgaMine · sulfate, 4-Guanidino-butylaMine · sulfate
  • AGMATINE SULFATE SALT(P)
  • 4-Guanidinobutylamine sulphate salt
  • guanidinobutane sulfate salt
  • Agmatine sulfate≥ 93% (HPLC)
  • matine SuL
  • 4minobutyl)guanidinium sulphate
  • Agmatine sulfate price
  • N-(4-Aminobutyl)guanidine sulfate sal
  • 1-Amino-4-guanidinobutane sulfate salt, 97% White to off-white powder
  • Agmatine Sulfate >
  • Guanidine, N-(4-aminobutyl)-, sulfate (1:1)
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  • 2-(4-aminobutyl)guanidine,sulfuricaci
  • High Quality Factory Supply Bulk Agmatine Sulfate
  • AGMATINE SULFATE /CAS 2482-00-0
  • 1-(4-Aminobutyl)guanidine sulfate(Chunks or pellets)
  • Agmatine sulftae(Fermented)
  • 1-AMINO-4-GUANIDINOBUTANE SULFATE SALT
  • AGMATINE SULPHATE
  • agmatine sulfate salt
  • 2-(4-aminobutyl)guanidine,sulfuric acid
  • gmatine sulfate
  • Guanidine butylamine sulfate
  • Agmatine sulfate(Fermented)
  • Agmatine sulfat
  • Agmatine sulfate, 2-(4-aminobutyl)guanidine sulfuric acid
  • Prinomastat Impurity 9
  • 2482-00-0
  • 2428-00-0
  • 2482-00-1
  • 2842-00-0
  • C5H16N4O4S
  • H2NCH24NHCNHNH2H2SO4
  • C5H14N4H2SO4C5H16N4O4S
  • C5H14N4H2SO4
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