2-IMINOTHIOLANE
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- CAS-Nr.
- 4781-83-3
- Englisch Name:
- 2-IMINOTHIOLANE
- Synonyma:
- 2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;2-IMINOTHIOLANE;thiolan-2-iMine;2-IMINOTHIOLANE HCL;IMinothiolane hydrochlorid;2-THIOLANIMINE HYDROCHLORIDE
- CBNumber:
- CB7373482
- Summenformel:
- C4H7NS.ClH
- Molgewicht:
- 137.63
- MOL-Datei:
- 4781-83-3.mol
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2-IMINOTHIOLANE Eigenschaften
- Schmelzpunkt:
- 198-201 °C(lit.)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: 100 mg/mL
- Aggregatzustand
- powder
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Freely soluble in water
- BRN
- 3620079
- CAS Datenbank
- 4781-83-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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2-IMINOTHIOLANE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.
Allgemeine Beschreibung
2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.
l?uterung methode
Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]
2-IMINOTHIOLANE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-IMINOTHIOLANE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 142)Lieferanten
4781-83-3()Verwandte Suche:
- 2-Iminothiolane hydrochloride,2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent
- thiolan-2-iMine
- 2(3H)-ThiopheniMine,dihydro-, hydrochloride (1:1)
- 2-Iminothiolane hydrochloride >=98% (TLC), powder
- IMinothiolane hydrochlorid
- Traut's reagent,2-Iminothiolane hydrochloride
- Dihydrothiophen-2(3H)-imine hydrochloride
- 2-Iminothiolane hydrochloride≥ 98% (HPLC)
- 2-THIOLANIMINE HYDROCHLORIDE
- 2-IMINOTHIOLANE
- 2-IMINOTHIOLANE HCL
- METHYL 4-MERCAPTOBUTYRIMIDATE HYDROCHLORIDE
- DIHYDRO-2(3H)-THIOPHENIMINE HYDROCHLORIDE
- Methyl-4-mercaptobutyrimidate hydrochloride 2-Iminothiolane hydrochloride
- 2(3H)-Thiophenimine, dihydro-, hydrochloride
- 2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Trauts reagent
- 2-Furancarboxyaldehyde, Reagent
- 2(3H)-Thiophenimine, dihydro-, dihydrochloride
- thiolan-2-imine hydrochloride
- TRAUT'S REAGENT
- 2-IMINOTHIOLANE HYDROCHLORIDE
- dihydrothiophen-2(3H)-iMine
- 2-Iminothiolane ,98%
- Nsc340007
- 2-Aminothiolidine hydrochloride
- 4781-83-3
- C4H7N1S1
- C4H7NSHCl
- C4H8ClNS
- BioChemical
- Reagents for lysine modification
- Protein Modification
- Proteomics and Protein Expression
- Proteomics
- Specific Amino Acid Modification
- Protein Modification Reagents
- MTS and Sulfhydryl Active Reagents
- MTS & Sulfhydryl Active Reagents
- Sulfur & Selenium Compounds
