Aftin-4
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- CAS-Nr.
- 866893-90-5
- Englisch Name:
- Aftin-4
- Synonyma:
- Aftin-4;Aftin-4 >=98% (HPLC);AFTIN-4;AFTIN 4;AFTIN4;N6-methyl-(R)-roscovitine;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
- CBNumber:
- CB73381022
- Summenformel:
- C20H28N6O
- Molgewicht:
- 368.48
- MOL-Datei:
- 866893-90-5.mol
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Aftin-4 Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Aftin-4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42). It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM.
In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice. It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.
Biochem/physiol Actions
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.
Aftin-4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Aftin-4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 64)Lieferanten
- Aftin-4
- AFTIN-4;AFTIN 4;AFTIN4
- N6-methyl-(R)-roscovitine
- 1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
- Aftin-4 >=98% (HPLC)
- (R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
- β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor
- 866893-90-5
- 66893-90-5
- C20H28N6O
