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Anti-POU domain, class 2, transcription factor 2

Anti-POU domain, class 2, transcription factor 2 Struktur
CAS-Nr.
Englisch Name:
Anti-POU domain, class 2, transcription factor 2
Synonyma:
Anti-OTF2;Anti-39723;Anti-2-Oct;Anti-MGC32628;Anti-POU domain, class 2, transcription factor 2;Monoclonal Anti-POU2F2 antibody produced in mouse;Monoclonal Anti-SLC22A2 antibody produced in mouse;Anti-solute carrier family 22 (organic cation transporter), member 2
CBNumber:
CB72916999
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-POU domain, class 2, transcription factor 2 Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous glycerol solution

Sicherheit

Anti-POU domain, class 2, transcription factor 2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-SLC22A2 antibody produced in mouse has been used in immunostaining.

Allgemeine Beschreibung

Solute carrier family 22 member 2 (SLC22A2) also known as organic cation transporter 2 (OCT2), is expressed prominently in the basolateral membrane of epithelial cells of kidney, especially in the proximal renal tubule. SLC22A2 possess 12 transmembrane domains and is the integral plasma membrane protein. In the human, SLC22A2 gene is mapped to chromosome 6q26.

Biochem/physiol Actions

Solute carrier family 22 member 2 (SLC22A2) is involved in the transport of cationic substances like drugs, toxins, waste metabolites like creatinine, neurotransmitters etc., from the kidney. Expression of SLC22A2 in kidney is regulated by methylation of the promoter region. The major substrate for SLC22A2 is metformin, an anti-diabetic agent. Lack of SLC22A2 leads possibly to drug toxicity as these substances are not eliminated from the body. Imipramine, clonidine, verapamil, quinidine, carvedilol, interact with SLC22A2 by hydrophobic interaction and leads to its inhibition.

Anti-POU domain, class 2, transcription factor 2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-POU domain, class 2, transcription factor 2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai guandao biology engineering co., ltd 18818239863 18818239863
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  • Anti-2-Oct
  • Anti-39723
  • Anti-OTF2
  • Anti-POU domain, class 2, transcription factor 2
  • Monoclonal Anti-POU2F2 antibody produced in mouse
  • Anti-MGC32628
  • Anti-solute carrier family 22 (organic cation transporter), member 2
  • Monoclonal Anti-SLC22A2 antibody produced in mouse
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