Molidustat(BAY 85-3934)
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- CAS-Nr.
- 1154028-82-6
- Englisch Name:
- Molidustat(BAY 85-3934)
- Synonyma:
- CS-1728;Somatoprim;MOLIDUSTAT;BAY 85-3934;Molidustat(BAY 85-3934);BAY 85-3934;BAY-85-3934;2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one;2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one;1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one;2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
- CBNumber:
- CB72729607
- Summenformel:
- C13H14N8O2
- Molgewicht:
- 314.3
- MOL-Datei:
- 1154028-82-6.mol
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Molidustat(BAY 85-3934) Eigenschaften
- Siedepunkt:
- 589.2±60.0 °C(Predicted)
- Dichte
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- insoluble in EtOH; insoluble in H2O; ≥5.68 mg/mL in DMF
- Aggregatzustand
- solid
- pka
- 5.38±0.37(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Molidustat(BAY 85-3934) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-
dependent degradation of the α subunit of HIF suppresses erythropoietin expression, stimulation of erythropoiesis by agents that prevent degradation of HIF has been one strategy for managing anemia. BAY 85-3934 stabilizes HIF from degradation in the proteasome by inhibiting HIF-
1α prolyl hydroxylase (IC
50 = 0.49 μM). Inhibition of HIF prolyl hydroxylase by BAY 85-3934 has been shown to increase endogenous production of erythropoietin. This compound has been investigated in clinical trial for treatment of patients with anemia associated with chronic kidney disease and/or end-
stage renal disease.
Molidustat(BAY 85-3934) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Molidustat(BAY 85-3934) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 99)Lieferanten
- Molidustat(BAY 85-3934)
- BAY 85-3934
- MOLIDUSTAT
- 2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
- 2-[6-(Morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
- Somatoprim
- 2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one
- 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one
- BAY 85-3934;BAY-85-3934
- 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one
- CS-1728
- 3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-
- 1154028-82-6
- 1154025-82-6
- C13H14N8O2
- Inhibitors
- API
