(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
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- CAS-Nr.
- 314771-76-1
- Englisch Name:
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
- Synonyma:
- Afatinib-1;Afatinib INT;Afatinib IMpurity B;afatinib impurities140;Afatinib intermediate D;Intermediates of sunitinib;Afatinib Impurity 1 ABCDEFGHJKL;3-furanyl]oxy]-4,6-quinazolinediamine;Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]
- CBNumber:
- CB72617898
- Summenformel:
- C18H16ClFN4O2
- Molgewicht:
- 374.8
- MOL-Datei:
- 314771-76-1.mol
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(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Eigenschaften
- Siedepunkt:
- 559.0±50.0 °C(Predicted)
- Dichte
- 1.473±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)
- pka
- 5.89±0.30(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Light Yellow to Light Beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthese
To a solution of 4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-[[(S)-tetrahydro-3-furanyl]oxy]-
quinazoline (1.34 g, 3.31 mmol) and ammonium chloride (496 mg, 9.27 mmol)
in anhydrous DMF (22 mL), Raney nickel [1.5 mL, 50 % (w/v) in water] was added to
the reaction mixture and stirred under an atmosphere of hydrogen at 40 °C for 2 h. After
2 h the reaction was diluted with EtOH (10 mL), filtered through diatomaceous earth
and washed with a large excess of EtOH. The residue was concentrated under reduced
pressure and purified by column chromatography eluting with CHCl3/MeOH (95:5) to
give 6 as a viscous brown oil (950 mg, 77 %).
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 252)Lieferanten
- 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
- 4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
- Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl
- N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
- Intermediates of sunitinib
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
- 7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl) aMino-6-aMinoquinazoline
- Afatinib IMpurity B
- Afatinib intermediate D
- N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]
- Afatinib INT
- 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydro-3-furanyl]oxy]quinazoline
- Afatinib-1
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
- 4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan -3-yl]oxyquinazoline-4,6-diamine
- (S)-N-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4
- 3-furanyl]oxy]-4,6-quinazolinediamine
- Afatinib Impurity 1 ABCDEFGHJKL
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine ISO 9001：2015 REACH
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamie
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)...
- afatinib impurities140
- 314771-76-1
- Afatinib Dimaleate
- 314771-76-1
