SMER 3
|
|
|
- CAS-Nr.
- 67200-34-4
- Englisch Name:
- SMER 3
- Synonyma:
- SMER 3;SMER3(SMER 3);SMER3, 10 mM in DMSO;5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;SMER3, SCFMet30 ubiquitin E3 ligase inhibitor;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
- CBNumber:
- CB72565931
- Summenformel:
- C11H4N4O2
- Molgewicht:
- 224.18
- MOL-Datei:
- 67200-34-4.mol
|
SMER 3 Eigenschaften
- Schmelzpunkt:
- 283-284 °C(Solv: ethanol (64-17-5))
- Siedepunkt:
- 437.2±55.0 °C(Predicted)
- Dichte
- 1.665±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥30mg/mL
- pka
- -8.15±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| WGK Germany |
1 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
SMER 3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
SMER3 is a selective inhibitor of Skp1-
Cullin-
F-
box (SCF)
MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-
cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCF
MET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.
Verwenden
SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.
SMER 3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SMER 3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 78)Lieferanten
67200-34-4()Verwandte Suche:
- SMER 3
- 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
- 9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
- OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
- SMER3(SMER 3)
- 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N
- 5-oxoinden[1,2-e]furazano[3,4-b]pyrazine
- Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
- SMER3, SCFMet30 ubiquitin E3 ligase inhibitor
- SMER3, 10 mM in DMSO
- 67200-34-4
- C11H4N4O2
