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TC-A 2317 hydrochloride

TC-A 2317 hydrochloride Struktur
1245907-03-2
CAS-Nr.
1245907-03-2
Englisch Name:
TC-A 2317 hydrochloride
Synonyma:
TC-A-2317 HCl;Reaxys ID: 20640556;TC-A 2317 hydrochloride;2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride;permeability,oral,Inhibitor,selective,antitumor,inhibit,HCT-116,TC A 2317 hydrochloride,TCA 2317 hydrochloride,Aurora Kinase,proliferation,TC-A 2317
CBNumber:
CB72535699
Summenformel:
C19H29ClN6O
Molgewicht:
392.93
MOL-Datei:
1245907-03-2.mol

TC-A 2317 hydrochloride Eigenschaften

storage temp. 
Store at 4°C
L?slichkeit
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Aggregatzustand
Powder

Sicherheit

TC-A 2317 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

TC-A2317 (TC-A 2317) is an orally active, potent and selective aurora A kinase inhibitor (Ki = 1.2 nM; Aurora B Ki = 101 nM; IC50 >1 μM toward 60 other kinases). TC-A2317 inhibits the proliferation of human colorectal carcinoma HCT116 cells in cultures (IC50 = 115 nM) and suppresses HCT116 xenograft-derived tumor growth in mice in vivo (by 59% on day 14; 30 mg/kg/day p.o.) with good pharmacokinectic properties, oral bioavailability (Tmax = 1.2 h, T1/2 = 3.3 h, Cmax = 4930 nM, C60 min = 52 nM in rat serum post 30 mg/kg p.o.), and no adverse effects to the animals. TC-A231 is a racemate with its (S)-enantiomer being more active than the (R)-enantiomer (respective Ki = 0.59 vs. 66 nM).

TC-A 2317 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


TC-A 2317 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 31991 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14055 65
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8140 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24649 58
ApexBio Technology --
sales@apexbt.com United States 6251 58

  • TC-A 2317 hydrochloride
  • TC-A-2317 HCl
  • 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride
  • Reaxys ID: 20640556
  • permeability,oral,Inhibitor,selective,antitumor,inhibit,HCT-116,TC A 2317 hydrochloride,TCA 2317 hydrochloride,Aurora Kinase,proliferation,TC-A 2317
  • 1245907-03-2
  • C19H28N6OClH
  • C19H28N6OHCl
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