3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
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- CAS-Nr.
- 860352-01-8
- Englisch Name:
- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
- Synonyma:
- CS-314;AZD 7762;White solid;AZD7762; AZD-7762;AZD-7762 Chk Inhibitor;1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea;(S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide;5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide;3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide;3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
- CBNumber:
- CB72473926
- Summenformel:
- C17H19FN4O2S
- Molgewicht:
- 362.42
- MOL-Datei:
- 860352-01-8.mol
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3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Eigenschaften
- Siedepunkt:
- 547.6±50.0 °C(Predicted)
- Dichte
- 1.38
- storage temp.
- -20°
- L?slichkeit
- Soluble in DMSO (up to at least 25 mg/ml).
- Aggregatzustand
- solid
- pka
- 9.06±0.20(Predicted)
- Farbe
- Yellow or brown
- Stabilit?t:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Actively proliferating cells experience blocks at certain checkpoints in the cell cycle when DNA damage is detected. These checkpoints allow for DNA damage repair before further cell cycle progression. Targeting signaling pathways to selectively inhibit repair at these checkpoints in tumor cells is of considerable interest to cancer therapeutics. AZD 7762 selectively inhibits the activity of checkpoint kinases (Chk) 1 and Chk2 (IC
50s = 5 nM) by competitively and reversibly binding their respective ATP-
binding sites (K
i = 3.6 nM for Chk1). AZD 7762 abrogates DNA damage-
induced S and G
2 checkpoints with an EC
50 value of 10 nM and potentiates the efficacy of DNA-
damage repair prohibitive agents, gemcitabine and topotecan, both
in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.
Verwenden
AZD 7762 is studied as an cancer therapeutic agent due to its selective inhibitory activities towards checkpoint kinases, chk1 and chk2 by reversibly binding their respective ATP-binding sites within
tumor cells. Recent research has also indicated AZD 7762 to possess enhancing effects towards other chk1 inhibitor lethality in glioblastoma cells.
3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 129)Lieferanten
860352-01-8()Verwandte Suche:
- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
- 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide
- AZD 7762
- White solid
- 1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea
- 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide AZD 7762
- AZD 7762
5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide
- (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide
- AZD7762; AZD-7762
- CS-314
- 2-Thiophenecarboxamide, 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-
- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide USP/EP/BP
- (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide hydrochloride
- 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide
- AZD-7762 Chk Inhibitor
- 860352-01-8
- 860325-01-8
- api
- Inhibitors
