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C5, HUMAN

C5, HUMAN Struktur
80295-53-0
CAS-Nr.
80295-53-0
Englisch Name:
C5, HUMAN
Synonyma:
C5, HUMAN;C5 Protein;COMPLEMENT C5;COMPLEMENT C5, HUMAN;COMPLEMENT C5 FROM HUMAN SERUM
CBNumber:
CB7239438
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

C5, HUMAN Eigenschaften

storage temp. 
-70°C
Aggregatzustand
Liquid

Sicherheit

Kennzeichnung gef?hrlicher B
WGK Germany  3

C5, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

Allgemeine Beschreibung

Native, human C5 complement component. Glycoprotein composed of two non-identical subunits of M.W. 120 kDa (α) and 75 kDa (β) linked by disulfide bonds. Present in normal human serum at 70 μg/ml. Activation of complement via either the classical or alternative pathway can result in the assembly of C5-cleaving enzymes (C5 convertases) on target surfaces. Both C5 convertases cleave the C5 α-chain at peptide bond 74 resulting in production of C5a (M.W. 11,200) and C5b fragments (M.W. 185,000). Released C5a peptide is one of the three complement-derived anaphylatoxins. C5b fragment combines with C6, C7, C8, and C9 to form lytic C5b-9 complement membrane attack complex (MAC).

Biochem/physiol Actions

Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.

C5, HUMAN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


C5, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Biolab Reagents 027-65279366 18108604862
products@biolabreagent.com China 9818 58
ACROBiosystems 18514007688
jiaxin.zhao@acrobiosystems.com China 1194 58

80295-53-0()Verwandte Suche:


  • C5, HUMAN
  • COMPLEMENT C5, HUMAN
  • COMPLEMENT C5
  • COMPLEMENT C5 FROM HUMAN SERUM
  • C5 Protein
  • 80295-53-0
  • Complement Proteins
  • Complement Factor Proteins
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • Cell Signaling Enzymes
  • Application Index
  • Complement Factor ProteinsProteins and Derivatives
  • Plasma Protein Composition
  • Complement Proteins
  • ComplementCell Signaling Enzymes
  • Plasma&Blood Proteins
  • Plasma, Blood, and Related Proteins and Reagents
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