4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NSC 207895 is an inhibitor of the p53-binding protein MDMX. It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 μmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 μmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC₅₀s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC₅₀s = 3,690-5,416 and 2,143 nM, respectively).

Verwenden

NSC-207895 is an anticancer agent and p53 activator. This compound decreases the expression of MDMX but also induced the expression of MDM2. It can also be used in pharmacological activity and therapeutic use of reviving antibiotics in relation to prepared efflux pump inhibitors that interact with AcrA, membrane fusion protein of AcrAB-TolC multidrug efflux pump.

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29815	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32063	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	23125	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

58131-57-0()Verwandte Suche:

---

• 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazan 3-oxide
• 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide
• 7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazane 1-oxide
• XI-006 (NSC207895)=1119
• NSC-207895
• NSC-207895 (XI-006)
• NSC 179940
• 4-(4-Methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole 3-oxide
• 2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide
• XI-006
• XI-006，NSC-207895
• 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide USP/EP/BP
• 7-(4-methylpiperazin-1-yl)-4-nitrobenzo[c][1,2,5]oxadiazole 1-oxide
• CS-230
• NSC-207895 NSC207895
• 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium
• 7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide
• 58131-57-0
• Inhibitors
• Inhibitor