3'-Chlorpropiophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

Chemische Eigenschaften

WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

Verwenden

3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

Application

3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.

synthetische

4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931

3'-Chlorpropiophenon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3'-Chlorpropiophenon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jinan Qinmu Fine Chemical Co.,Ltd.	+8618660799346	sales@qinmuchem.com	China	1009	58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD	+8617731987558	xingjiu@xingjiubiotech.com	China	989	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	80	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8806	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20283	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	clara@hbshengyang.com	China	875	58

34841-35-5(3'-Chlorpropiophenon)Verwandte Suche:

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• 3-CHLOROPHENYL ETHYL KETONE
• (3-CHLOROPHENYL)PROPAN-1-ONE
• 1-(3-CHLOROPHENYL)-1-PROPANONE
• 3-CHLORO-1-PHENYL-PROPANONE
• 3-CHLOROPROPIOPHENONE M-CHLORO PROPIOPHENONE
• 3-Chloro-Propiophenone(M-ChloroProiophenone)
• M-ChloroProiophenone
• 3'-Chloropropiophenone
• 3'-Chloropropiopheno
• Between chloropropiophenone
• 1-Propanone, 1-(3-chlorophenyl)-
• Bupropion Des-t-ButylaMino IMpurity
• 3&priMe
• 3'-chloroacetone
• ：3’-Chloropropiophenone，1-(3-chlorophenyl)propan-1-one
• 3 '- chlorobenzene acetone
• 3'-Chloropropiophenone Synonyms 1-(3-Chlorophenyl)-1-propanone
• 3'-Chloropropiophenone, 97+%
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• Bupropion Impurity 14 (3'-Chloropropiophenone)
• Bupropion Impurity 22
• Bupropion Hydrochloride Impurity Ⅰ（3-chloropropiophenone）
• Chloropropiophenone Chloropropiophenone
• MCPP 3'-Chloropropiophenone
• 3'-Chloropropiophenone USP/EP/BP
• 3'-Chloropropiophenone/META CHLOROPROPIOPHENONE
• 3’-ChloropropiophenoneQ: What is 3’-Chloropropiophenone Q: What is the CAS Number of 3’-Chloropropiophenone Q: What is the storage condition of 3’-Chloropropiophenone Q: What are the applications of 3’-Chloropropiophenone
• 1-(3-Chlorphenyl)propan-1-on
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• M-CHLOROPROPIOPHENONE
• MCPP
• 1-(3-chlorophenyl)propan-1-one
• Bupropion Hydrochloride Impurity Ⅰ (3-chloropropiophenone)
• DES-T-BUTYLAMINO IMPURITY
• Meta Chloropropiophenone
• 3-chlorophenone
• Bupropion Intermediate
• Meta - Chloropropiophenone ( 3 - Chloropropiophenone )
• Chloropropiophenone (10 mg) (1-(3-Chlorophenyl)propan-1-one) (COLD SHIPMENT REQUIRED)
• 3'-Chloropropiophenone, ≥ 98.0%
• 3'-Chloropropiophenone
• Bupropion Hydrochloride Impurit Ⅰ： 3'-Chloropropiophenone
• Bupropion Des-tert-butylamine Impurity
• Bupropion Impurity 48
• 1-(3-Chlorophenyl)propan-1-one (Bupropion Impurity)
• 34841-35-5
• Organic Building Blocks
• Ketones
• Building Blocks
• Carbonyl Compounds
• C9
• KETONE
• C9
• Carbonyl Compounds
• Ketones
• Aromatic Propiophenones (substituted)
• Aromatic Ketones (substituted)
• Aromatic Halides (substituted)