Methyl 2-(hydroxymethyl)isonicotinate
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- CAS-Nr.
- 58481-17-7
- Englisch Name:
- Methyl 2-(hydroxymethyl)isonicotinate
- Synonyma:
- Methyl 2-(hydroxyMethyl)
isonicotinate;2-Hydroxymethyl-isonicotinic acid methyl ester;Methyl 2-(hydroxymethyl)pyridine-4-carboxylate;2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester;2-(Hydroxymethyl)Isonicotinic Acid
2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
- CBNumber:
- CB71558141
- Summenformel:
- C8H9NO3
- Molgewicht:
- 167.16
- MOL-Datei:
- 58481-17-7.mol
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Methyl 2-(hydroxymethyl)isonicotinate Eigenschaften
- Siedepunkt:
- 304.2±32.0 °C(Predicted)
- Dichte
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.20±0.10(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Methyl 2-(hydroxymethyl)isonicotinate Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
The reaction was performed in 2 separate 1000 mL round-bottomed flasks. To a solution of methyl isonicotinate (70 g, 510.44 mmol) and sulfuric acid (2.340 mL, 43.90 mmol) in MeOH (700 mL) under reflux added a solution of ammonium peroxydisulfate (210 g, 918.80 mmol) in water (350 mL) over 20 min. The reaction was refluxed for 20 min and was then allowed to cool to room temperature. The solid was filtered off and washed with MeOH. After that, MeOH was removed from the filtrate under reduced pressure and then neutralized by cautious stepwise addition of solid Na2CO3 under ice-cooling. The aqueous solution was extracted with ethyl acetate and the combined organic layers were dried with Na2SO4 and evaporated. The dark-brown residue was treated with cyclohexane (3×300 mL) and the cyclohexane phase was decanted. The remaining dark-brown residue was purified by automated flash chromatography on 2 Biotage KP-SIL 340 g columns. A gradient from 25% to 100% of EtOAc in heptane over 10 CV was used as the mobile phase. Methyl 2-(hydroxymethyl)isonicotinate (27.5 g, 32%) was isolated.
Methyl 2-(hydroxymethyl)isonicotinate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 2-(hydroxymethyl)isonicotinate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 81)Lieferanten
- 2-Hydroxymethyl-isonicotinic acid methyl ester
- 4-Pyridinecarboxylic acid, 2-(hydroxyMethyl)-, Methyl ester
- 2-(Hydroxymethyl)Isonicotinic Acid
2(HYDROXYMETHYL)4PYRIDINECARBOXYLIC ACID
- Methyl 2-(hydroxyMethyl)
isonicotinate
- Methyl 2-(hydroxymethyl)pyridine-4-carboxylate
- 2-(hydroxymethyl)-4-Pyridinecarboxylic acid methyl ester
- 58481-17-7
