Chlorozotocin Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).
Verwenden
Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).
Sicherheitsprofil
Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Poison by subcutaneous,
intravenous, and intraperitoneal routes.
Human systemic effects by intravenous
route: anorexia, leukopenia, nausea or
vomiting, thrombocytopenia. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx. See
also NITROSAMINES.
Carcinogenicity
Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.
Chlorozotocin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
