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Chlorozotocin

Chlorozotocin Struktur
54749-90-5
CAS-Nr.
54749-90-5
Englisch Name:
Chlorozotocin
Synonyma:
CZT;DCNU;CHLZ;CCRIS 879;NCS-178248;NCS-D-254157;Chlorozotocin;2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE;D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
CBNumber:
CB71178262
Summenformel:
C9H16ClN3O7
Molgewicht:
313.69
MOL-Datei:
54749-90-5.mol

Chlorozotocin Eigenschaften

Schmelzpunkt:
147-148° (dec with the evolution of gas); mp 140-141° (dec)
Siedepunkt:
119.3°C (rough estimate)
Dichte
1.6475 (rough estimate)
Brechungsindex
1.6000 (estimate)
pka
9.08±0.46(Predicted)
IARC
2A (Vol. 50) 1990
EPA chemische Informationen
Chlorozotocin (54749-90-5)

Sicherheit

RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
Giftige Stoffe Daten 54749-90-5(Hazardous Substances Data)

Chlorozotocin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).

Verwenden

Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.

Carcinogenicity

Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.

Chlorozotocin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlorozotocin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
TargetMol Chemicals Inc.

support@targetmol.com United States 38460 58
PT CHEM GROUP LIMITED

peter68@ptchemgroup.com China 35425 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19863 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 19699 58

54749-90-5()Verwandte Suche:


  • CZT
  • DCNU
  • NCS-178248
  • NCS-D-254157
  • Chlorozotocin
  • 2-(3-(2-CHLOROETHYL)-3-NITROSOUREIDO)-D-GLUCOPYRANOSE
  • CHLZ
  • D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
  • CCRIS 879
  • 54749-90-5
  • C9H16ClN3O7
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