Ambrisentan
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Ambrisentan Eigenschaften
- Schmelzpunkt:
- >150°C (dec.)
- Siedepunkt:
- 551.1±60.0 °C(Predicted)
- Dichte
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 0.97±0.10(Predicted)
- Farbe
- White to Off-White
- Merck
- 14,384
- InChI
- InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
- InChIKey
- OUJTZYPIHDYQMC-UHFFFAOYSA-N
- SMILES
- C(OC1N=C(C)C=C(C)N=1)(C(O)=O)C(OC)(C1=CC=CC=C1)C1=CC=CC=C1
Sicherheit
R-S?tze: | 62/63 | ||
---|---|---|---|
S-S?tze: | 53-36/37/39-45 | ||
RTECS-Nr. | UA2459660 | ||
HS Code | 29335990 |
Ambrisentan Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.Chemische Eigenschaften
White to Off White SolidVerwenden
Nonpeptide endothelin ETA receptor antagonist. AntihypertensiveAllgemeine Beschreibung
Ambrisentan, (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.Ambrisentan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ambrisentan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 377)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 |
market@hopelife.cn | China | 72 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 456 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32957 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
177036-94-1()Verwandte Suche:
4-Methoxyphenol
Folsure
2-Methoxyphenol
Diphenylether
Anisaldehyd
Anisol
1,5-Diphenylcarbonohydrazid
Propionsure
POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
Phenylvalerat
(Trifluormethoxy)benzol
4-Methoxyphenylacetonitril
ASCORBICACID
PHENYL RESIN
3,3-Diphenylpropionsure
Phenylessigsure
4,6-Dimethylpyrimidin-2-ol
Methoxy
- BSF 208075,(+)-(2S)-2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)OXY]-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- AMBRISENTAN
- (aS)-a-[(4,6-Dimethyl-2-pyrimidinyl)oxy]--methoxy--phenylbenzenepropanoic Acid
- BSF 208075
- LU 208075
- 2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
- (S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid
- (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid,bsf-208075
- Ambrisentan Tablets
- Benzenepropanoic acid, α-[(4,6-diMethyl-2-pyriMidinyl)oxy]-β-Methoxy-β-phenyl-, (αS)-
- Benzenepropanoic acid, alpha-[(4,6-diMethyl-2-pyriMidinyl)oxy]-beta-Methoxy-beta-phenyl-, (alphaS)-
- (αS)-α-[(4,6-DiMethyl-2-pyriMidinyl)oxy]-β-Methoxy-β-phenylbenzenepropanoic Acid
- (R,S)-AMbrisentan-d5
- AMbrisentan (BSF 208075)
- Benzenepropanoic acid, a-[(4,6-diMethyl-2-pyriMidinyl)oxy]-b-Methoxy-b-phenyl-, (aS)-
- LU-208075,BSF-208075
- Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
- Ambrisentan, >=98%
- (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
- ambrisentan,CID 6918493
- CS-135
- Anrisentan API
- (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic Acid
- Ambrisentan USP/EP/BP
- ((S)-Ambrisentan)
- AmbrisentanQ: What is Ambrisentan Q: What is the CAS Number of Ambrisentan Q: What is the storage condition of Ambrisentan Q: What are the applications of Ambrisentan
- Ambelsentan intermediate
- (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoicaci
- Ambrisentan 98% 177036-94-1
- Ambrisentan AKSci B500
- (R,S)-Ambrisentan
- Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
- Anlisentan
- 177036-94-1
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