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  • Ambrisentan

    Ambrisentan Struktur
    177036-94-1
    CAS-Nr.
    177036-94-1
    Englisch Name:
    Ambrisentan
    Synonyma:
    CS-135;LU 208075;BSF 208075;Anlisentan;AMBRISENTAN;Anrisentan API;((S)-Ambrisentan);(R,S)-Ambrisentan;Ambrisentan, >=98%;Ambrisentan Tablets
    CBNumber:
    CB71011125
    Summenformel:
    C22H22N2O4
    Molgewicht:
    378.42
    MOL-Datei:
    177036-94-1.mol

    Ambrisentan Eigenschaften

    Schmelzpunkt:
    >150°C (dec.)
    Siedepunkt:
    551.1±60.0 °C(Predicted)
    Dichte
    1.228±0.06 g/cm3(Predicted)
    storage temp. 
    Sealed in dry,2-8°C
    L?slichkeit
    DMSO (Slightly), Methanol (Slightly)
    Aggregatzustand
    Solid
    pka
    0.97±0.10(Predicted)
    Farbe
    White to Off-White
    Merck 
    14,384
    InChI
    InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
    InChIKey
    OUJTZYPIHDYQMC-UHFFFAOYSA-N
    SMILES
    C(OC1N=C(C)C=C(C)N=1)(C(O)=O)C(OC)(C1=CC=CC=C1)C1=CC=CC=C1

    Sicherheit

    R-S?tze: 62/63
    S-S?tze: 53-36/37/39-45
    RTECS-Nr. UA2459660
    HS Code  29335990

    Ambrisentan Chemische Eigenschaften,Einsatz,Produktion Methoden

    Beschreibung

    Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.

    Chemische Eigenschaften

    White to Off White Solid

    Verwenden

    Nonpeptide endothelin ETA receptor antagonist. Antihypertensive

    Allgemeine Beschreibung

    Ambrisentan, (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.

    Ambrisentan Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Ambrisentan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 377)Lieferanten
    Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
    Beijing Hope Pharmaceutical Co., Ltd.
    +86-010-67886402 +8613611125266
    market@hopelife.cn China 72 58
    BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
    +86-18600796368 +86-18600796368
    sales@sjar-tech.com China 456 58
    Capot Chemical Co.,Ltd.
    +86-(0)57185586718 +86-13336195806
    sales@capot.com China 29791 60
    Beijing Cooperate Pharmaceutical Co.,Ltd
    010-60279497
    sales01@cooperate-pharm.com CHINA 1803 55
    Henan Tianfu Chemical Co.,Ltd.
    +86-0371-55170693 +86-19937530512
    info@tianfuchem.com China 21634 55
    Nanjing ChemLin Chemical Industry Co., Ltd.
    025-83697070
    product@chemlin.com.cn CHINA 3009 60
    ATK CHEMICAL COMPANY LIMITED
    +undefined-21-51877795
    ivan@atkchemical.com China 32957 60
    Lianyungang happen teng technology co., LTD
    15950718863
    wang666xt@163.com CHINA 295 58
    career henan chemical co
    +86-0371-86658258 +8613203830695
    sales@coreychem.com China 29880 58
    Hubei Jusheng Technology Co.,Ltd.
    18871490254
    linda@hubeijusheng.com CHINA 28172 58

    177036-94-1()Verwandte Suche:


    • BSF 208075,(+)-(2S)-2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)OXY]-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
    • AMBRISENTAN
    • (aS)-a-[(4,6-Dimethyl-2-pyrimidinyl)oxy]--methoxy--phenylbenzenepropanoic Acid
    • BSF 208075
    • LU 208075
    • 2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
    • (S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid
    • (+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid,bsf-208075
    • Ambrisentan Tablets
    • Benzenepropanoic acid, α-[(4,6-diMethyl-2-pyriMidinyl)oxy]-β-Methoxy-β-phenyl-, (αS)-
    • Benzenepropanoic acid, alpha-[(4,6-diMethyl-2-pyriMidinyl)oxy]-beta-Methoxy-beta-phenyl-, (alphaS)-
    • (αS)-α-[(4,6-DiMethyl-2-pyriMidinyl)oxy]-β-Methoxy-β-phenylbenzenepropanoic Acid
    • (R,S)-AMbrisentan-d5
    • AMbrisentan (BSF 208075)
    • Benzenepropanoic acid, a-[(4,6-diMethyl-2-pyriMidinyl)oxy]-b-Methoxy-b-phenyl-, (aS)-
    • LU-208075,BSF-208075
    • Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
    • Ambrisentan, >=98%
    • (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
    • ambrisentan,CID 6918493
    • CS-135
    • Anrisentan API
    • (S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic Acid
    • Ambrisentan USP/EP/BP
    • ((S)-Ambrisentan)
    • AmbrisentanQ: What is Ambrisentan Q: What is the CAS Number of Ambrisentan Q: What is the storage condition of Ambrisentan Q: What are the applications of Ambrisentan
    • Ambelsentan intermediate
    • (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoicaci
    • Ambrisentan 98% 177036-94-1
    • Ambrisentan AKSci B500
    • (R,S)-Ambrisentan
    • Benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
    • Anlisentan
    • 177036-94-1
    • APIs
    • Aromatics
    • Heterocycles
    • Intermediates & Fine Chemicals
    • Pharmaceuticals
    • Other APIs
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