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BE-43547

BE-43547 Struktur
CAS-Nr.
Englisch Name:
BE-43547
Synonyma:
BE-43547
CBNumber:
CB69380710
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

BE-43547 Eigenschaften

Sicherheit

BE-43547 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BE-43547 is a bacteria-derived, which targets hypoxic cells independently of reductases. It was isolated as a mixture of congeners (A1-C2) from Micromonospora sp. The macrocyclic depsipeptide BE-43547, produced by some bacteria in hypoxic niches, possibly to kill competing microorganisms, shows selective cytotoxicity against hypoxic cells. The compound was recently shown to covalently target eukaryotic translation elongation factor 1 alpha 1 (eEF1A1) under oxic conditions. Under hypoxia, BE-43547 induces necrotic cell death involving rapid loss of mitochondrial function and integrity with phenotypic similarities to ferroptosis, yet lacking the critical markers of this type of cell death. The hypoxia-selective toxicity of BE-43547 is shared with the structurally related rakicidin-family of natural products; however, BE-43547 displayed enhanced hypoxia selectivity when tested in pancreatic PANC-1 cells. Furthermore, the full potential of this drug remains uncertain, including benchmarking against a lead bioreductive agent[1].

BE-43547 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BE-43547 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Accendatech Co., Ltd.
+8613132578992
yunhao.liu@accendatech.com China 251 58
Tianjin Shangde Medicine Edge Technology Co., Ltd 13370460931
sales@accendatech.com China 11 58

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