成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Trifluridin

Trifluridine Struktur
70-00-8
CAS-Nr.
70-00-8
Bezeichnung:
Trifluridin
Englisch Name:
Trifluridine
Synonyma:
TFT;TRIFLUOROTHYMIDINE;viroptic;f3t;nsc75520;Triflurdine;Triflurdine (Viroptic);Thymidine, α,α,α-trifluoro-;2,4(1h,3h)-pyrimidinedione,1-(2-deoxy-beta-d-ribofuranosyl)-5-(trifluorometh;FTD
CBNumber:
CB6768812
Summenformel:
C10H11F3N2O5
Molgewicht:
296.2
MOL-Datei:
70-00-8.mol

Trifluridin Eigenschaften

Schmelzpunkt:
190-193 °C (lit.)
Dichte
1.4365 (estimate)
Brechungsindex
50 ° (C=1, H2O)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 14 mg/ml)
Aggregatzustand
solid
pka
pKa 7.85 (Uncertain)
Farbe
Off-white
Merck 
14,9687
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
CAS Datenbank
70-00-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 20/21/22-40
S-S?tze: 22-36
WGK Germany  3
RTECS-Nr. XP2087500
Hazard Note  Keep Cold
HS Code  29349990
Giftige Stoffe Daten 70-00-8(Hazardous Substances Data)
Toxizit?t LD50 intraperitoneal in mouse: 1931mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Trifluridin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. It is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity. After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes. Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Trifluridine is used as anti-herpesvirus antiviral agent in ophthalmie preparations.

Definition

ChEBI: Trifluridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis. It has a role as an antiviral drug, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor and an antineoplastic agent. It is a nucleoside analogue, an organofluorine compound and a pyrimidine 2'-deoxyribonucleoside.

Indications

Trifluridine (Viroptic) is a fluorinated pyrimidine nucleoside that has in vitro activity against HSV-1 and HSV- 2, vaccinia, and to a lesser extent, some adenoviruses. Activation of trifluridine requires its conversion to the 5 monophosphate form by cellular enzymes.Trifluridine monophosphate inhibits the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) by thymidylate synthetase. In addition, it competes with deoxythymidine triphosphate (dTTP) for incorporation by both viral and cellular DNA polymerases. Trifluridine-resistant mutants have been found to have alterations in thymidylate synthetase specificity.

Allgemeine Beschreibung

Trifluridine, 5-trifluoromethyl-29-deoxyuridine (Viroptic),is a fluorinated pyrimidine nucleoside that demonstrates invitro inhibitory activity against HSV-1 and HSV-2, CMV,vaccinia, and some adenoviruses.Trifluridine possesses atrifluoromethyl group instead of an iodine atom at the 5-position of the pyrimidine ring.
synthetase, and the biologically generated triphosphatecompetitively inhibits thymidine triphosphate incorporationinto DNA by DNA polymerase. In addition, trifluridine inits triphosphate form is incorporated into viral and cellularDNA, creating fragile, poorly functioning DNA.Trifluridine is approved in the United States for the treatmentof primary keratoconjunctivitis and recurrent epithelialkeratitis caused by HSV types 1 and 2. Topical trifluridineshows some efficacy in patients with acyclovir-resistantHSV cutaneous infections.

Mechanism of action

Trifluorothymidine is a fluorinated pyridine nucleoside structurally related to idoxuridine. It has been approved by the U.S. FDA and is a potent, specific inhibitor of replication of HSV-1 in vitro. Its mechanism of action is similar to that of idoxuridine. Like other antiherpes drugs, it is first phos-phorylated by thymidine kinase to mono-, di-, and triphosphate forms, which are then incorporated into viral DNA in place of thymidine to stop the formation of late virus mRNA and subsequent synthesis of the virion proteins.

Pharmakokinetik

Trifluorothymidine is a synthetic halogenated pyrimidine nucleoside, first synthesized as an antitumor agent. It inhibits enzymes of the DNA pathway and is incorporated into both cellular and progeny viral DNA, causing faulty transcription of late messenger RNA and the production of incompetent virion protein. It does not require a viral thymidine kinase for monophosphorylation and is far less selective and more toxic than other analogs. It is active against HSV-1 and HSV-2, vaccinia virus, CMV and possibly adenovirus. Trifluorothymidine, when given IV, shows a plasma half-life of 18 minutes and is excreted in the urine either unchanged or as the inactive metabolite 5-carboxyuracil. When applied as a 1% ophthalmic solution, it rapidly enters the aqueous humor of HSV-infected rabbits’ eyes but is cleared within 60–90 min.

Nebenwirkungen

The most frequent adverse reactions to trifluridine administration are transient burning or stinging and palpebral edema. Other adverse reactions include superficial punctate keratopathy, epithelial keratopathy, hypersensitivity, stromal edema, irritation, keratitis sicca, hyperemia, and increased intraocular pressure.
Trifluridine is mutagenic in vitro and carcinogenic and teratogenic when administered subcutaneously to animals. Topical trifluridine was not teratogenic in animal studies. Because it is applied topically in humans, the likelihood of systemic effects is low.

Trifluridin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trifluridin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 402)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Beijing Ribio Biotech Co.,Ltd
010-62664360 +8613328773880
wucy@ribio.com.cn China 117 58
Cangzhou Kangrui Pharma Tech Co. Ltd.,
+86-18632776803 +86-13833998158
cangzhoukangrui@126.com China 738 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 965 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58

70-00-8(Trifluridin)Verwandte Suche:


  • 5-TRIFLUORO THYMIDINE
  • 2''-DEOXY-5-(TRIFLUOROMETHYL)URIDINE (TRIFLUOROTHYMIDINE)
  • 2’-deoxy-5-(trifluoromethyl)-uridin
  • 5-(trifluoromethyl)deoxyuridine
  • 5-trifluoro-2’-deoxythymidine
  • alpha,alpha,alpha-trifluoro-thymidin
  • f3dthd
  • 5-TRIFLUOROTHYMIDINE extrapure (Trifluridine)
  • α,α,α-Trifluorothymidine, 2μ-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine
  • 2'-Deoxy-5-trifluoromethyluridine, Trifluridine
  • Trifluridine (100 mg)
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-5-(trifluoroMethyl)-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • Trifluridine API
  • alpha,alpha,alpha-Trifluorothymidine Trifluridine 2'-Deoxy-5-trifluoromethyluridine
  • FTD
  • NSC 529182
  • Trifluridine, Trifluorothymidine, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-(trifluoromethyl)uracil
  • 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-(trifluoroMethyl)pyriMidine-2,4(1H,3H)-dione
  • Trifluorothymidine (TFT)
  • Trifluridine(FTD)
  • TRIFLUORO-D-THYMIDINE
  • TRIFLURIDINE
  • TRIFLUOROTHYMINE DEOXYRIBOSIDE
  • tfdu
  • trifluoromethyldeoxyuridine
  • 2'-DEOXY-5-TRIFLUOROMETHYLURIDINE
  • ALPHA,ALPHA,ALPHA-TRIFLUOROTHYMIDINE
  • Trifluridine, Trifluorothymine Deoxyriboside, a,a,a-Trifluorothymidine
  • 2'-DEOXY-5-(TRIFLUOROMETHYL)URIOINE
  • 2''-DEOXY-5-(TRILIUOROMETHYL)URIDINE
  • 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE
  • F3TDR
  • Trafluuridine
  • MA-1 hydrochloride
  • Trifluridina
  • Fluorine urea glycosides
  • Trifluorothymidine, 5-Trifluoromethyl-2’-deoxyuridine
  • Trifluridine USP/EP/BP
  • Trifluridine (trifluorothymidine)
  • TIANFU-CHEM Trifluridine
  • 5-Trifluorothymidine extrapure, 99%
  • Trifluridine (1686309)
  • Trifluridine (Viroptic)
  • VIROPTIC; TRIFLUOROTHYMIDINE
  • 2,4(1h,3h)-pyrimidinedione,1-(2-deoxy-beta-d-ribofuranosyl)-5-(trifluorometh
  • f3t
  • nsc75520
  • TFT
  • TRIFLUOROTHYMIDINE
  • viroptic
  • Triflurdine
  • Thymidine, α,α,α-trifluoro-
  • Triflurdine (Viroptic)
  • Viroptic, Trifluorothymidine, F3Thd
  • 3,6-Dihydro-3-methyl-N-nitro-2H-1,3,5-oxadiazin-4-amine 153719-38-1
  • 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione
  • 2'-5-CF3-dU
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione
Copyright 2019 ? ChemicalBook. All rights reserved