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14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Struktur
42895-58-9
CAS-Nr.
42895-58-9
Englisch Name:
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Synonyma:
AP 10;14-dehydro Andrographolide;Andrographolide Impurity 1;14-deoxy11,12 deoxyandrographolide;14-Deoxy-11,12-didehydroandrographol;Deoxy 11,14-didehydroandrographolide;14-Deoxy-11,14-didehydroandrographolide;11,12-Didehydro-14-deoxyandrographolide;14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE;Deoxy-11,12-Didehydroandrographolide, 14-
CBNumber:
CB6735337
Summenformel:
C20H28O4
Molgewicht:
332.43
MOL-Datei:
42895-58-9.mol

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Eigenschaften

Schmelzpunkt:
204-205℃
Siedepunkt:
519.6±50.0 °C(Predicted)
Dichte
1.17
storage temp. 
Store at -20°C
L?slichkeit
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
pka
14.80±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

WGK Germany  3

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

Verwenden

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 122)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
Xi'an Kono chem co., Ltd.,
029-86107037 13289246953
info@konochemical.com China 2993 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29814 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 23125 58
Labnetwork lnc.
+86-27-50766799 +8618062016861
contact@labnetwork.com China 19987 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58

42895-58-9()Verwandte Suche:


  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
  • 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone
  • ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide
  • 11,12-Didehydro-14-deoxyandrographolide
  • 14-Deoxy-11,14-didehydroandrographolide
  • AP 10
  • Deoxy-11,12-Didehydroandrographolide, 14-
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • 3-[(E)-2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-6α-hydroxy-5,8aα-dimethyldecahydronaphthalene-1α-yl]ethenyl]-2,5-dihydrofuran-2-one
  • 3-[(E)-2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-(hydroxymethyl)-5,8aα-dimethyl-2-methylenenaphthalen-1-yl]vinyl]furan-2(5H)-one
  • 14-Deoxy-11,12-didehydroandrographol
  • 14-Deoxy-11,12-didehydroandrographolide16,15-olide
  • 3,19-Dihydroxylabda-8(17),11,13-trien-16,15-olide
  • 3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one
  • 14-Deoxy-11,12-didehydroandrographolide?, >98%
  • 2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-
  • 14-dehydro Andrographolide
  • 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE USP/EP/BP
  • Andrographolide Impurity 1
  • 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one
  • 14-deoxy11,12 deoxyandrographolide
  • 14 - deoxy11,12-12 dehydroandrographolide
  • 14-Deoxy 11,14-didehydroandrographolide-RM
  • Deoxy 11,14-didehydroandrographolide
  • 42895-58-9
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