APHIDICOLIN
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- CAS-Nr.
- 38966-21-1
- Englisch Name:
- APHIDICOLIN
- Synonyma:
- APC;ici69653;nsc-234714;APHIDICOLIN;(+)-APHIDICOLIN;,11a-beta,11b-beta))-;APHIDICOLIN USP/EP/BP;Aphidicolin, Ready Made Solution;(+)-APHIDICOLIN, NIGROSPORA ORYZAE;Aphidicolin, froM Nigrospora oryzae
- CBNumber:
- CB6683304
- Summenformel:
- C20H34O4
- Molgewicht:
- 338.48
- MOL-Datei:
- 38966-21-1.mol
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APHIDICOLIN Eigenschaften
- Schmelzpunkt:
- 218-220°C
- alpha
- D27 +12° (c = 1 in methanol)
- Siedepunkt:
- 394.61°C (rough estimate)
- Dichte
- 1.0057 (rough estimate)
- Dampfdruck
- 0.55 hPa ( 20 °C)
- Brechungsindex
- 1.4434 (estimate)
- Flammpunkt:
- 87℃
- storage temp.
- 2-8°C
- L?slichkeit
- ethanol: soluble1mg/mL (stable at least a week at 4°C.)
- Aggregatzustand
- White solid
- pka
- 14.24±0.70(Predicted)
- Farbe
- colorless
- Optische Aktivit?t
- [α]27/D +12°, c = 1 in methanol(lit.)
- Wasserl?slichkeit
- Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°
- Merck
- 13,734
- BRN
- 4689958
- Stabilit?t:
- Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
APHIDICOLIN Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24:Berührung mit der Haut vermeiden.
Beschreibung
(+)-
Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus
C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-
permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels. Aphidicolin can be used, at 3 μM, to arrest cells in G
1/S phase or to increase gene amplification frequency.
Chemische Eigenschaften
White crystal
Verwenden
(+)-Aphidicolin is a naturally occurring tetracyclic diterpene with potential antiviral and antimitotical properties.
Definition
ChEBI: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positi
ns 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
Allgemeine Beschreibung
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
APHIDICOLIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
APHIDICOLIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 134)Lieferanten
38966-21-1()Verwandte Suche:
- (3-ALPHA,4-ALPHA,5-ALPHA,17-ALPHA)-3,17-DIHYDROXY-4-METHYL-9,15-CYCLO-C,18-DINOR-14,15-SECOANDROSTANE-4,17-DIMETHANOL
- (+)-APHIDICOLIN
- APHIDICOLIN
- (+)-APHIDICOLIN, NIGROSPORA ORYZAE
- ,11a-beta,11b-beta))-
- 9-dimethanol,tetradecahydro-3,9-11a-methano-11ah-cyclohepta(a)naphthalene-4
- dihydroxy-4,11b-dimethyl-,(3r-(3-alpha,4-alpha,4a-alpha,6a-beta,8-beta,9-beta
- ici69653
- nsc-234714
- APHIDICOLIN FROM CEPHALOSPORIUM APHIDICO LA
- APHIDICOLIN FROM NIGROSPORA SPHAERICA
- 8,11a-Methano-11aH-cycloheptaanaphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
- Aphidicolin, froM Nigrospora oryzae
- 8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
- Aphidicolin NSC 234714 ICI 69653
- Aphidicolin, Ready Made Solution
- Aphidicolin - CAS 38966-21-1 - Calbiochem
- InSolution Aphidicolin - CAS 38966-21-1 - Calbiochem
- APHIDICOLIN USP/EP/BP
- Aphidicolin, 98%, from Nigrospora oryzae
- (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
- APC
- 8,11|á-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
- (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-Bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol
- 38966-21-1
- BioChemical
- Antibiotics A to Z
- Antibiotics A-F
- Antibiotics
- antibiotic
- Di-Terpenoids
