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Dipivefrine

Dipivefrine Struktur
52365-63-6
CAS-Nr.
52365-63-6
Englisch Name:
Dipivefrine
Synonyma:
K30081;K 30081;K-30081;DIPIVEFRIN;dipiverfrin;dipivefrine;Dipivefrina;Dipivefrinum;Dipivefrine-d3;Dipivefrine USP/EP/BP
CBNumber:
CB6676807
Summenformel:
C19H29NO5
Molgewicht:
351.44
MOL-Datei:
52365-63-6.mol

Dipivefrine Eigenschaften

Schmelzpunkt:
146-147°
pka
pKa 8.40(RT) (Uncertain)

Sicherheit

Dipivefrine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Adrenergic (ophthalmic).

Allgemeine Beschreibung

Toovercome several of the pharmacokinetic and pharmaceuticalshortcomings of E as an ophthalmic agent, the prodrugapproach has been successfully applied. Dipivefrin is a prodrugof E that is formed by the esterification of the catecholOH groups of E with pivalic acid. Most of the advantages ofthis prodrug over E stem from improved bioavailability. Thegreatly increased lipophilicity allows much greater penetrabilityinto the eye through the corneal epithelial andendothelial layer. The stroma in between requires hydrophilicityfor penetration. Dipivefrin has that, too, due tothe 1-OH group and cationic nitrogen (the eyedrops containthe hydrochloride [HCl] salt). This dual solubility permitsmuch greater penetrability into the eye than the very hydrophilicE hydrochloride. Increased DOA is also achievedbecause the drug is resistant to the metabolism by COMT.In addition to its increased in vivo stability, it is also lesseasily oxidized by air due to the protection of the catecholOH groups. This high bioavailability and in vivo and in vitrostability translate into increased potency such that the 0.1%ophthalmic solution is approximately equivalent to a 2% Esolution. After its absorption, it is converted to E by esterasesslowly in the cornea and anterior chamber.Dipivefrin also offers the advantage of being less irritatingto the eye than E.

Dipivefrine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dipivefrine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 28)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Chemwill Asia Co.,Ltd. 86-21-51086038
chemwill_asia@126.com CHINA 23912 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Shanghai Send Pharmaceutical Technology Co., Ltd. 021-58088081 Q3382968513
hailey@shsendpharm.com China 3129 55
Shanghai Resuperpharmtech Co., Ltd. 02150565560; 17321237488
kevin@resuperpharmtech.com China 358 58
BOC Sciences --
info@bocsci.com USA 0 65

52365-63-6()Verwandte Suche:


  • DIPIVEFRIN
  • dipivefrine
  • Propanoic acid, 2,2-dimethyl-, 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester
  • Propanoic acid, 2,2-dimethyl-, 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester, (+-)-
  • [2-(2,2-dimethylpropanoyloxy)-5-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate
  • 2,2-dimethylpropionic acid [5-[1-hydroxy-2-(methylamino)ethyl]-2-pivaloyloxy-phenyl] ester
  • [2-(2,2-dimethylpropanoyloxy)-4-(1-hydroxy-2-methylamino-ethyl)- phenyl] 2,2-dimethylpropanoate
  • dipiverfrin
  • Dipivefrine for system suitability CRS
  • Dipivefrine-d3
  • Propanoic acid, 2,2-dimethyl-, 1,1'-[4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene] ester
  • Dipivefrine USP/EP/BP
  • Dipivefrina
  • Dipivefrinum
  • K 30081
  • K30081
  • K-30081
  • 52365-63-6
  • C19H29NO5
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