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Suberohydroxamic acid

Suberohydroxamic acid Struktur
38937-66-5
CAS-Nr.
38937-66-5
Englisch Name:
Suberohydroxamic acid
Synonyma:
ODHA;SBHA;[PTYR705]-STAT3;STAT3 (PTYR705);SUBEROHYDROXAMIC ACID;SUBERIC BISHYDROXAMATE;SuberohydroxaMic acid 95%;SuberoylBis-hydroxamicAci;suberic bishydroxamic acid;SUBEROYL BISHYDROXAMIC ACID
CBNumber:
CB6673028
Summenformel:
C8H16N2O4
Molgewicht:
204.22
MOL-Datei:
38937-66-5.mol

Suberohydroxamic acid Eigenschaften

Schmelzpunkt:
153-155 °C(lit.)
Dichte
1.219±0.06 g/cm3(Predicted)
storage temp. 
−20°C
L?slichkeit
H2O: soluble
pka
9.18±0.20(Predicted)
Aggregatzustand
lyophilized powder
Farbe
White to Light Beige
Stabilit?t:
Hygroscopic

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
HS Code  2928009090

Suberohydroxamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.

Verwenden

Histone deacetylase inhibitor. A cell-permeable inhibitor of HDAC1 and HDAC3. Shown to suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells.

Biologische Aktivit?t

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.

Suberohydroxamic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Suberohydroxamic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Kindchem(Nanjing)Co.,Ltd
+86-025-025-85281586 +8618651653755
sales@kindchem.cn China 1226 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18150 58
PNP Biotech Co. Ltd
+8618516098983
sales@pnpbiotech.com China 1001 58
Dalian Ruiying Technology Co., Ltd.
+86-0411-86907150 +86-15940963210
609262758@qq.com China 578 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Hebei Weibang Biotechnology Co., Ltd
+8615350571055
Sibel@weibangbio.com China 6086 58

38937-66-5()Verwandte Suche:


  • ODHA
  • OCTANE-1,8-DIHYDROXAMIC ACID
  • SBHA
  • SUBERIC BISHYDROXAMATE
  • SUBEROHYDROXAMIC ACID
  • SUBEROYL BISHYDROXAMIC ACID
  • STAT3 (PTYR705)
  • [PTYR705]-STAT3
  • Octane-1,8-dihydroxamic acid (ODHA)
  • Octanediamide, N1,N8-dihydroxy-
  • SuberohydroxaMic acid 95%
  • N,N′-Dihydroxyoctanediamide
  • N1,N8-Dihydroxyoctanediamide
  • SBHA - CAS 38937-66-5 - Calbiochem
  • suberic bishydroxamic acid
  • SuberoylBis-hydroxamicAci
  • 38937-66-5
  • -CH23CONHOH2
  • Organic Building Blocks
  • Nitrogen Compounds
  • Hydroxylamines
  • Building Blocks
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Hydroxylamines
  • Nitrogen Compounds
  • Organic Building Blocks
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