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RETINOL BINDING PROTEIN FROM HUMAN URINE

RETINOL BINDING PROTEIN FROM HUMAN URINE Struktur
CAS-Nr.
Englisch Name:
RETINOL BINDING PROTEIN FROM HUMAN URINE
Synonyma:
RETINOL BINDING PROTEIN FROM HUMAN URINE
CBNumber:
CB6567044
Summenformel:
C20H30O
Molgewicht:
286.4516
MOL-Datei:
Mol file

RETINOL BINDING PROTEIN FROM HUMAN URINE Eigenschaften

storage temp. 
−20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

Kennzeichnung gef?hrlicher B
WGK Germany  3

RETINOL BINDING PROTEIN FROM HUMAN URINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Retinol Binding Protein from human urine has been used:
  • as one of the protein in microinjecting mesencephalic cavity of chicken eggs to monitor embryonic cerebrospinal fluid/embryonic serum protein transfer
  • as an additive in basal medium for RNA transfection experiments
  • in the antibody-derivatized affinity pipettes preparation for the capture of affinity proteins

Allgemeine Beschreibung

Retinol Binding Protein (RBP) is a member of lipocalin superfamily. The normal concentration of RBP in serum is 40 to 50 μg/mL and has a molecular weight of 21 kDa. It has a turnover rate of 4 to 24 h. RBP is produced in the liver in response to retinol binding trigger. It is also produced in kidney, sertoli cells of testis. RBP contains a single globular domain and a highly conserved N-terminal region. It has eight antiparallel β sheets in the centre which binds retinol. In human chromosome, the gene encoding RBP is localised at 3q23.

Biochem/physiol Actions

Retinol Binding Protein (RBP) is a specific protein for the transport of vitamin A. The apo-RBP, formed after delivering retinol to the tissues is catabolized by the kidney. The plasma concentration of RBP is less in diabetes mellitus patients. RBP binds to the carrier protein transerythrin, to prevent its loss during glomerular filtration. RBP is implicated in initial neurogenesis and neuroepithelial cell proliferation. RBP is responsible for blepharophimosis syndrome (BPES).

RETINOL BINDING PROTEIN FROM HUMAN URINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


RETINOL BINDING PROTEIN FROM HUMAN URINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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