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RS 102895

RS 102895 Struktur
300815-41-2
CAS-Nr.
300815-41-2
Englisch Name:
RS 102895
Synonyma:
1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS 102895 HYDROCHLORIDE;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
CBNumber:
CB6504368
Summenformel:
C21H21F3N2O2
Molgewicht:
390.4
MOL-Datei:
300815-41-2.mol

RS 102895 Eigenschaften

Siedepunkt:
446.1±45.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Desiccate at RT
L?slichkeit
DMSO: 18 mg/mL, clear, colorless
Aggregatzustand
powder
pka
13.46±0.20(Predicted)
Farbe
white

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3

RS 102895 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biologische Aktivit?t

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

RS 102895 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RS 102895 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 99)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040
 sales@myuchem.com China 7629 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208
 sales@aochuangchem.com China 9245 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203
 info@chemextension.com China 42056 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
  • 1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • RS 102895 HYDROCHLORIDE
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one
  • 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-
  • 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
  • CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895
  • 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
  • 300815-41-2
  • C21H21F3N2O2HCl
  • RS 102895 CCR2-selective chemokine receptor antagonist.
  • Cytokine signaling
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