7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.

Allgemeine Beschreibung

A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC₅₀ at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck_64-509 Y³⁹⁴, Lckcd pY³⁹⁴, Src, Kdr and Tie-2, respectively; IC₅₀ at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck_64-509 Y³⁹⁴, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC₅₀ = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC₅₀<1-40 nM in Jurkat T cells) and in vivo (ED₅₀ = 4 mg/kg in mice, ip.)

Biochem/physiol Actions

Primary TargetLck?????? Y3

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32024	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	sales@dogechemical.com	China	4128	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

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• 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
• 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• RK-24466 ;RK 24466 ;RK24466
• Lck Inhibitor - CAS 213743-31-8 - Calbiochem
• d]pyrimidin-4-ylamine
• RK-24466
• KIN 001-51
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-cyclopentyl-5-(4-phenoxyphenyl)-
• KIN001-051
• RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466
• 4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
• 213743-31-8
• LckNon-Receptor Tyrosine Kinase Biology
• Lymphocyte Specific Kinase (Lck)Cell Signaling and Neuroscience
• Non-Receptor Tyrosine Kinase Inhibitors
• Enzyme Inhibitors by Enzyme
• Kinase/Phosphatase Biology
• L to
• Protein Kinase Inhibitors