Lansoprazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Lansoprazole is the second proton pump inhibitor approved as an antiulcer agent for the short term treatment of duodenal ulcer and gastroesophageal reflux disease. Like omeprazole, lansoprazole is reported to be more efficacious than the H₂-antagonists in treating peptic ulcer disease.Other potential uses could be in the treatment of Zollinger-Ellison syndrome.

Chemische Eigenschaften

White Crystalline Powder

Verwenden

Used as a gastric proton pump inhibitor. An antiulcerative

Allgemeine Beschreibung

Lansoprazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole(Prevacid), is a white to brownish white, odorless crystallinepowder that is practically insoluble in water.Lansoprazole is a weak base (pyridine N, pKa 3.83.) and aweak acid (benzimidazole N-H, pK 0.62). Like other PPIs,lansoprazole is essentially a prodrug that, in the acidic biophaseof the parietal cell, forms an active metabolite thatirreversibly interacts with the target ATPase of the pump.Lansoprazole must be formulated as encapsulated entericcoatedgranules for oral administration to protect the drugfrom the acidic environment of the stomach.
In the fasting state, about 80% of a dose of lansoprazole(vs. 50% of omeprazole) reaches the systemic circulation,where it is 97% bound to plasma proteins. Thedrug is metabolized in the liver (sulfone and hydroxymetabolites) and excreted in bile and urine, with a plasmahalf-life of about 1.5 hours.

Biologische Aktivit?t

H + ,K + -ATPase inhibitor (IC 50 = 6.3 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.09 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro . Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole ).

Lansoprazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Lansoprazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8803	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12825	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	484	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	025-87151996	zbsales@chinaredsun.com	CHINA	32	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	7033	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55

103577-45-3()Verwandte Suche:

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• LANSOPRAZOLE, MM(CRM STANDARD)
• LANSOPRAZOLE USP(CRM STANDARD)
• 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1h-benz
• OGAST
• LANSOPRAZOLE
• LANSAPRAZOLE
• LANSOX
• LANZOR
• LIMPIDEX
• lfinyl)-
• 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1h-benzoimidazole
• A-65006
• Lansoprazole99.5%
• A-65006, AG-1749, Agopton, Lansox, Lanzor, Limpidex, Ogast, Prevacid,
• 1H-Benzimidazole, 2-3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinylmethylsulfinyl-
• LANSORAZOLE
• 1H-Benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]- (9CI)
• 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
• Ilsatec
• Ketian
• Lancid
• Lanfast
• Lanproton
• Lansopep
• Lanz
• Lanzol 30
• Lanzopral
• Ogastro
• PP/K-10
• Promp
• Prosogan
• Suprecid
• Takepron
• Ulpax
• Zoton
• Lansopranzole
• 1H-1,3-benzimidazol-2-yl (4-ethoxy-3-methyl-2-pyridinyl)methyl sulfoxide
• 2-[[[3-Methyl-4-(2，2，2-trifluoroethoxy)-2-pyridinyl]methyl]methyl]sulfinyl]-1Hbenzimidazole
• 1h-benzimidazole,2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)su
• AG-1749
• AGOPTON
• (1H-Benzimidazole-2-yl)[4-(2,2,2-trifluoroethoxy)-3-methyl-2-pyridylmethyl] sulfoxide
• Taiproton
• Lansoprazole (150 mg)G0D3070.995mg/mg(ai)
• 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]sulfinyl]-
• 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
• Alter
• Cinfa
• Davur
• Lanpro
• Lanso
• Lansofast
• Lansophed
• Lansor
• Lanston
• Lansoprazole (150 mg)
• 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]Methyl]sulfinyl]-1H-benziMidazole, (+)-2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]sulfinyl]-1H-benziMidazole, 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-yl]Methylsulfinyl]benziMida
• PREVONCO LANSOPRAZOLE