Tolfenaminsure
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- CAS-Nr.
- 13710-19-5
- Bezeichnung:
- Tolfenaminsure
- Englisch Name:
- Tolfenamic acid
- Synonyma:
- CLOTAM;gea6414;Tolfedine;Tolfenamic;olfenamicaci;Toxamic acid;Tofenamic acid;TOLFENAMIC ACID;TOLEFNAMIC ACID;Tolfenamic acid CRS
- CBNumber:
- CB6365693
- Summenformel:
- C14H12ClNO2
- Molgewicht:
- 261.7
- MOL-Datei:
- 13710-19-5.mol
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Tolfenaminsure Eigenschaften
- Schmelzpunkt:
- 210-214°C
- Siedepunkt:
- 405.4±40.0 °C(Predicted)
- Dichte
- 1.2037 (rough estimate)
- Brechungsindex
- 1.5270 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
- Aggregatzustand
- Solid
- pka
- 3.66±0.36(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
- Merck
- 14,9513
- InChIKey
- YEZNLOUZAIOMLT-UHFFFAOYSA-N
- CAS Datenbank
- 13710-19-5(CAS DataBase Reference)
- EPA chemische Informationen
- Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
CB2687500 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
29224919 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tolfenaminsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Chemische Eigenschaften
White Solid
Verwenden
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
Allgemeine Beschreibung
Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.
Tolfenaminsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tolfenaminsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 284)Lieferanten
13710-19-5(Tolfenaminsure)Verwandte Suche:
- LABOTEST-BB LT00772313
- TOLFENAMIC ACID
- 2-((3-chloro-2-methylphenyl)amino)-benzoicaci
- gea6414
- n-(2-methyl-3-chlorophenyl)anthranilicacid
- 2-(3-CHLORO-O-TOLUIDINO)BENZOIC ACID
- 2 (3-CHLORO-2-METHYLANILINO)BENZOIC ACID
- 2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID
- 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid
2-(3-Chloro-o-toluidino)benzoic Acid
Tolfenamic Acid
- Tolfenamic acid Solution, 100ppm
- 2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid
- 2-[(4-Chloro-3-methylphenyl)amino]benzoic acid
- Tolfedine
- 2-[(3-Chloro-o-tolyl)amino]benzoic acid
- n-(3-chloro-o-tolyl)-anthranilicaci
- CLOTAM
- n-(3-chloro-o-tolyl)-anthranilicacid
- N-(3-CHLORO-2-METHYLPHENYL)ANTHRANILIC ACID
- n-(3-chloro-ortho-tolyl) anthranilic acid
- Tolfenamic
- Benzoic acid, 2-(3-chloro-2-methylphenyl)amino-
- N-(3-Chloro-ortho-tolyl) anthranilic acid solution,100ppm
- Tolfenamic Acid:2-((3-Chloro-2-methylphenyl)amino)benzoic acid
- Tolfenamic Acid Standard
- N-(3-Chloro-2-methylphenyl)anthranilic Acid >
- Tolfenamic acid CRS
- Tolfenamic acid USP/EP/BP
- Tolfenamic Acid (GEA 6414)
- N-(3-Chloro-ortho-tolyl) anthranilic acid 13710-19-5
- olfenamicaci
- TOLEFNAMIC ACID
- Tofenamic acid
- Toxamic acid
- C17591000 TolfenamiCacid
- Tolfenamic acid 100 μg/ml Acetonitrile
- 13710-19-5
- 13710-19-1
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- Enzymes, Inhibitors, and Substrates
- Substrate Analogs
- BioChemical
- Biochemicals and Reagents
- CLOTAM
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Active Pharmaceutical Ingredients
