(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

Suspension of 2- bromo- 4- nitroimidazole (100 g), 2- methyl- 2- oxiranylmethyl (S)- 4- nitrobenzenesulfonate (142.4 g), potassium carbonate (93.6 g), caesium fluoride (15.8 g) and dimethylformamide (420 ml) was stirred at 35- 40°C for 26 hours. The reaction mixture was poured into water (1.2 litres) and then extracted twice with ethyl acetate (1 litre). The ethyl acetate layers were combined after being washed twice with water (1.2 liters), washed with an aqueous solution (800 ml) saturated with sodium chloride, then dried over anhydrous magnesium sulfate. After being filtrated under reduced pressure, the filtrate was concentrated under a reduced pressure. The thus obtained residue was purified by use of a silica gel column chromatography (eluent: n-hexane/ ethyl acetate = 1/1), there was obtained (R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole (110.9 g, yield: 81%) as a yellow powdery product.

(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD	+86-19925801629 +86-19925801629	eric@huarongpharma.com	China	243	58
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	sales@zhiwe.net	China	628	61
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4330	58
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD	19925801629	eric@huarongpharma.com	China	134	58

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• DE-8
• 2-bromo-1-[[(2R)-2-methyloxiran-2-yl]methyl]-4-nitroimidazole
• 1H-Imidazole, 2-bromo-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro-
• (R)-2-bromo-1-(2-methyl-2-oxiranylmethyl)-4-nitroimidazole
• 681484-60-6