Epalrestat
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- CAS-Nr.
- 82159-09-9
- Englisch Name:
- Epalrestat
- Synonyma:
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Ipast;Eabeth;Epatat;Kinedak;Epa－API;Ipastat;ONO 2235
- CBNumber:
- CB6312501
- Summenformel:
- C15H13NO3S2
- Molgewicht:
- 319.4
- MOL-Datei:
- 82159-09-9.mol
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Epalrestat Eigenschaften
- Schmelzpunkt:
- 210-217 C
- Siedepunkt:
- 516.8±60.0 °C(Predicted)
- Dichte
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 3.62±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow to orange
- Merck
- 14,3605
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- InChI
- InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
- InChIKey
- CHNUOJQWGUIOLD-NFZZJPOKSA-N
- SMILES
- S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
2811 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
XJ5131855 |
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| HS Code |
2932.99.7000 |
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| HazardClass |
6.1 |
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| PackingGroup |
II |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Epalrestat Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the
first to be launched in Japan. The compound is indicated for the treatment of diabetic
neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.
Chemische Eigenschaften
Red Solid
Verwenden
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM
Definition
ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor
of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Epalrestat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Epalrestat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 470)Lieferanten
82159-09-9()Verwandte Suche:
- 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
- e)-(e
- EPALRESTAT
- (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
- AKOS BBS-00007767
- OTAVA-BB BB7211260020
- Epalrest
- Epalrestat, 99.5%
- EPALRESTAT(KINEDAK)
- 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
- ONO 2235
- Epalresta
- 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
- Epatrestat
- 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
- 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
- Eabeth
- Epatat
- Quinedac
- Kinedak
- (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
- (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid
- He IpaneMa Division
- 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
- Epalrestat>
- Epalrestat Epalrestat
- Epalrestat RS
- 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
- Epalrestat USP/EP/BP
- Epalrestat (ONO2235)
- EpalrestatQ: What is
Epalrestat Q: What is the CAS Number of
Epalrestat Q: What is the storage condition of
Epalrestat Q: What are the applications of
Epalrestat
- Epa－API
- Ipastat
- According to Mr He
- 2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
- Antidiabetic API
- Ipasetam
- Ipast
- 82159-09-9
- 81259-09-9
- C15H13NO3S2
- API
- Hormone Drugs
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- API's
- Treatment of diabetic neuropathy
- 82159-09-9
