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XMU-MP-1

XMU-MP-1 Struktur
2061980-01-4
CAS-Nr.
2061980-01-4
Englisch Name:
XMU-MP-1
Synonyma:
4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide;CS-2590;XMU-MP-1;XUM-MP- 1;PubChem ID: 121499143;XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1;4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide;Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
CBNumber:
CB63122127
Summenformel:
C17H16N6O3S2
Molgewicht:
416.48
MOL-Datei:
2061980-01-4.mol

XMU-MP-1 Eigenschaften

Siedepunkt:
714.8±70.0 °C(Predicted)
Dichte
1.523±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
≥41.6 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Aggregatzustand
powder
pka
9.77±0.12(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

XMU-MP-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2 (IC50s = 71.1 and 38.1 nM, respectively). It is selective for MST1 and 2 over a panel of 468 kinases at a concentration of 1 μM. XMU-MP-1 inhibits phosphorylation of MOB1, LATS1 and 2, and YAP in HepG2 cells as well as MST1 and 2 autophosphorylation in RAW 264.7, U2OS, SW480, RPE1, SNU423, and HepG2 cells in a concentration-dependent manner. It also prevents cell death induced by overexpression of MST2. XMU-MP-1 (1 mg/kg) enhances liver regeneration in mice post partial hepatectomy and reduces liver fibrosis in a mouse model of chronic liver injury.

Verwenden

XMU-?MP-?1 an MST1/2 inhibitor.

XMU-MP-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

XMU-MP-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 80)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32951 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32072 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574
 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38465 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Suzhou Chukai Pharma Tech Co.,Ltd 		+8615062531973
 2279973922@qq.com China 367 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658
 sales1@artkmedchem.com China 39004 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • XMU-MP-1
  • PubChem ID: 121499143
  • CS-2590
  • 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
  • Benzenesulfonamide, 4-[(6,10-dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]-
  • 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino)benzenesulfonamide
  • XMU MP 1,Inhibitor,Hippo (MST),inhibit,XMUMP1
  • XUM-MP- 1
  • 2061980-01-4
  • API
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