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Sappanone A

Sappanone A Struktur
102067-84-5
CAS-Nr.
102067-84-5
Englisch Name:
Sappanone A
Synonyma:
Sappanone A;3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one;(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one;3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
CBNumber:
CB63037515
Summenformel:
C16H12O5
Molgewicht:
284.26
MOL-Datei:
102067-84-5.mol

Sappanone A Eigenschaften

Siedepunkt:
605.5±55.0 °C(Predicted)
Dichte
1.521±0.06 g/cm3(Predicted)
L?slichkeit
DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.25 mg/ml
Aggregatzustand
A solid
pka
7.20±0.20(Predicted)
Farbe
Light yellow to yellow

Sicherheit

Sappanone A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.

Verwenden

Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.

Biologische Aktivit?t

Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.

Sappanone A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sappanone A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
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  • Sappanone A
  • 3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
  • (E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one
  • 3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one
  • 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
  • 102067-84-5
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