Raloxifene hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemische Eigenschaften

Light-Yellow Solid

Verwenden

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Raloxifene hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Raloxifene hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1243	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9312	58
Wuhan Godbullraw Chemical Co.,ltd	+undefined18986288449	Alisasales@godbullraw.com	China	553	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Hong Kong Excellence Biotechnology Co., Ltd.		ada@sh-teruiop.com	China	875	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
zhuzhou dingcheng meihei comestic co.,ltd	+8618873369619	dingchengbusiness8@163.com	China	260	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	269	58
Hebei Mojin Biotechnology Co.,Ltd	+86-15028179902	angelia@hbmojin.com	China	1176	58

82640-04-8()Verwandte Suche:

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• RALOXIFENE HCL
• Raloxifene hydrochloride,Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
• Raloxifene Hydrochloride (200 mg)
• 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol hydrochloride
• (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone hydrochloride
• Evista(Raloxifene Hydrochloride
• (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanon
• [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone,hydrochloride (1:1)
• LY156758 (Keoxifene) HCl
• Evista (Raloxifene HCl)
• Methanone,[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-,hydrochloride (1:1)
• (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)metha
• RALOXIFENE HYDROCHLORIDE
• KEOXIFENE
• KEOXIFENE HYDROCHLORIDE
• LY 139481
• AKOS 92138
• ly156758
• methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin
• [6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL][4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-METHANONE HYDROCHLORIDE
• [6-Hydroxy-2-(4-Hydroxyphenyl) benzo[b]thien-3-yl]
• RALOXIFENEHYDROCHLORIDE(SUBJECTTOPATENTFREE)
• Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
• 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl) ethoxy]phenyl]methanone HCl
• Raloxifene Hydrochloride Tablets
• LY156758 hydrochloride
• CS-127
• LY139481 hydrochloride
• Raloxifene hydrochloride,>98%
• [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride
• Raloxifene hydrochloride USP/EP/BP
• Latilavir secondary VI
• Raloxifene hydrochloride Evista
• [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
• Raloxefene hydrochloride
• Raloxifene HCl (LY-139481)
• Raloxifene hydrochloride (Y0001134)
• Raloxifene Hydrochloride (1598201)
• (1aΞ,7aΞ)-1a-methyl-7a-[(2E,7RS,11RS)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (trans-epoxyphytomenadione isomers)
• RALOXFENE HCL
• 82640-04-8
• 28640-04-8
• C28H27NO4S.HCl
• C28H27NO4SClH
• C28H27NO4SHClC28H28ClNO4S
• API
• Pharmaceutical intermediate
• Inhibitors
• antifungal
• Aromatics
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Sulfur & Selenium Compounds
• Active Pharmaceutical Ingredients
• Raloxifene
• Intracellular receptor