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4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid

NPGB Struktur
19135-17-2
CAS-Nr.
19135-17-2
Bezeichnung:
4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid
Englisch Name:
NPGB
Synonyma:
NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
CBNumber:
CB6287205
Summenformel:
C14H13ClN4O4
Molgewicht:
336.73
MOL-Datei:
19135-17-2.mol

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Eigenschaften

Schmelzpunkt:
241-243 °C
storage temp. 
-20°C
Aggregatzustand
Solid
Farbe
White to off-white
BRN 
8024554
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36
S-S?tze: 26
WGK Germany  3
F  8-10
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36:Reizt die Augen.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Verwenden

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
  • as a substrate for trypsin for active site titration experiments
  • for pre-treating of mosquito eggs in the interplasmid transposition assay
  • as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

Allgemeine Beschreibung

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.

Einzelnachweise

[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 14)Lieferanten
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Shanghai Guchen Biotechnology Co., LTD 021-34675735 19147740836
 1986399151@qq.com China 9844 58

19135-17-2(4-Nitrophenyl-4-[(aminoiminomethyl)amino]benzoatmonohydrochlorid)Verwandte Suche:

  • 4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
  • NPGB
  • PNPGB
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE
  • P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE
  • P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE
  • Nsc163801
  • 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HCL
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE &
  • p-nitrophenyl-p'-guanidinobenzoateHClcrystalline
  • p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline
  • Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride
  • 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
  • (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride
  • 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate
  • 19135-17-2
  • C14H12N4O4HCl
  • Substrates by Enzyme
  • Chromogenic
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Substrates
  • Activity
  • BioChemical
  • Biochemicals and Reagents
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