CHLAMYDOCIN
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- CAS-Nr.
- 53342-16-8
- Englisch Name:
- CHLAMYDOCIN
- Synonyma:
- SL-3440;CHLAMYDOCIN;Antibiotic SL-3440;2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-];Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl];Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
- CBNumber:
- CB6283843
- Summenformel:
- C28H38N4O6
- Molgewicht:
- 526.63
- MOL-Datei:
- 53342-16-8.mol
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CHLAMYDOCIN Eigenschaften
- Siedepunkt:
- 861.8±65.0 °C(Predicted)
- Dichte
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO: soluble; Ethanol: soluble; Methanol: soluble
- Aggregatzustand
- A solid
- pka
- 13.36±0.70(Predicted)
CHLAMYDOCIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Chlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from
D. chlamydosporia and has anticancer properties. It is selective for HDAC1 over HDAC6 (IC
50 = 0.15 and 1,100 nM, respectively). Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM. It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC
50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg.
Verwenden
Chlamydocin is a cyclic tetrapeptide and an irreversible histone deacetylase (HDAC) inhibitor.
CHLAMYDOCIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CHLAMYDOCIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 23)Lieferanten
- Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
- CHLAMYDOCIN
- 2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]
- Antibiotic SL-3440
- SL-3440
- Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl]
- 53342-16-8
- C28H38N4O6
- Antibiotic
