3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
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- CAS-Nr.
- 890190-22-4
- Englisch Name:
- 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
- Synonyma:
- WDR5-0103;WDR50103, >98%;WDR5(WDR5-0103);WD-Repeat Protein 5-0103;WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103;Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate;3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester;Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester
- CBNumber:
- CB62695169
- Summenformel:
- C21H25N3O4
- Molgewicht:
- 383.44
- MOL-Datei:
- 890190-22-4.mol
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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Eigenschaften
- Siedepunkt:
- 495.2±45.0 °C(Predicted)
- Dichte
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- pka
- 12.96±0.70(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50/53 |
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| S-S?tze: |
60-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
WD-
repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-
modifying protein complexes with histones. For example, WDR5 is a component of a mixed-
lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones. WDR5-
0103 is a small molecule that binds a peptide-
binding pocket on WDR5 (K
d = 450 nM), inhibiting the catalytic activity of the MLL core complex
in vitro (IC
50 = 39 μM).
Verwenden
3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic Acid Methyl Ester is an small molecule inhibitor of WDR5, an essential componet of the human trithorax-like famliy of SET1 methyltransferase complexes that carry out trimethylation of histone 3 Lys4.
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 89)Lieferanten
- 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
- Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
- WDR5-0103
- WDR50103, >98%
- WD-Repeat Protein 5-0103
- WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103
- Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester
- WDR5(WDR5-0103)
- 890190-22-4
- Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
