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3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Struktur
1254977-87-1
CAS-Nr.
1254977-87-1
Englisch Name:
3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
Synonyma:
CS-2446;JNJ42153605 (on going);JNJ-42153605;JNJ42153605;Inhibitor,JNJ42153605,Metabotropic glutamate receptors,JNJ-42153605,inhibit,JNJ 42153605,mGluR;3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine;3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine;1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-
CBNumber:
CB62618641
Summenformel:
C22H23F3N4
Molgewicht:
400.44
MOL-Datei:
1254977-87-1.mol

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Eigenschaften

Dichte
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF:30.0(Max Conc. mg/mL);74.92(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.62(Max Conc. mM)
DMSO:10.34(Max Conc. mg/mL);25.81(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);24.97(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
3.07±0.30(Predicted)
Farbe
White to off-white

Sicherheit

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 43)Lieferanten
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  • 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
  • JNJ42153605 (on going)
  • JNJ-42153605;JNJ42153605
  • CS-2446
  • 3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine
  • 1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-
  • Inhibitor,JNJ42153605,Metabotropic glutamate receptors,JNJ-42153605,inhibit,JNJ 42153605,mGluR
  • 1254977-87-1
  • C22H23F3N4
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