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PF-04457845

PF-04457845 Struktur
1020315-31-4
CAS-Nr.
1020315-31-4
Englisch Name:
PF-04457845
Synonyma:
CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
CBNumber:
CB62522724
Summenformel:
C23H20F3N5O2
Molgewicht:
455.43
MOL-Datei:
1020315-31-4.mol

PF-04457845 Eigenschaften

Siedepunkt:
687.0±55.0 °C(Predicted)
Dichte
1.389±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
pka
12.72±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

PF-04457845 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

PF-04457845 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)- 3-Hydroxybenzylalkohol 2-Chlor-5-(trifluormethyl)pyridin

Downstream Produkte

PF-04457845 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 73)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
  • N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
  • PF-04457845
  • N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide
  • PF-04457845;PF04457845
  • 1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
  • N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide
  • CS-1549
  • PF-04457845 >=98% (HPLC)
  • Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor
  • 1020315-31-4
  • C23H20F3N5O2
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