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VEGFR2 Kinase Inhibitor II

VEGFR2 Kinase Inhibitor II Struktur
288144-20-7
CAS-Nr.
288144-20-7
Englisch Name:
VEGFR2 Kinase Inhibitor II
Synonyma:
VEGFR2 Kinase Inhibitor II;VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II;VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem;(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one;2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-
CBNumber:
CB62501837
Summenformel:
C17H15BrN2O
Molgewicht:
343.22
MOL-Datei:
288144-20-7.mol

VEGFR2 Kinase Inhibitor II Eigenschaften

storage temp. 
-20C
L?slichkeit
DMF: 20 mg/ml; DMSO: 10 mg/ml
Aggregatzustand
Brown solid

Sicherheit

VEGFR2 Kinase Inhibitor II Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM).

Biochem/physiol Actions

Cell permeable: yes

VEGFR2 Kinase Inhibitor II Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


VEGFR2 Kinase Inhibitor II Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
BOC Sciences 16314854226
info@bocsci.com United States 9923 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
Jinan ponder chemical co. LTD 0531-0000
thinklifescience@163.com China 19689 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8140 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11974 58

  • VEGFR2 Kinase Inhibitor II
  • (3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indol-2-one
  • VEGFR2 Kinase Inhibitor II - CAS 288144-20-7 - Calbiochem
  • 2H-Indol-2-one, 5-bromo-1,3-dihydro-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-, (3Z)-
  • VEGFR2 Kinase Inhibitor II,VEGFR-2 Kinase Inhibitor II
  • 288144-20-7
  • Angiogenesis and Metastasis
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