(S)-Ketorolac
|
|
|
- CAS-Nr.
- 66635-92-5
- Englisch Name:
- (S)-Ketorolac
- Synonyma:
- Ketorolac S-IsoMer;(S)-Ketorolac ISO 9001：2015 REACH;Ketorolac impurity 2/Ketorolac S-Isomer;Phosphorousacid,tris(1,5-dimethylethyl)ester;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
- CBNumber:
- CB62485724
- Summenformel:
- C15H13NO3
- Molgewicht:
- 255.27
- MOL-Datei:
- 66635-92-5.mol
|
(S)-Ketorolac Eigenschaften
- Schmelzpunkt:
- 160-167?C
- Siedepunkt:
- 493.2±40.0 °C(Predicted)
- Dichte
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- L?slichkeit
- Chloroform: Slightly; Ethanol: >1mg/ml; Methanol: Slightly
- Aggregatzustand
- A crystalline solid
- pka
- 4.29±0.20(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
|
(S)-Ketorolac Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC
50s = 0.1 and 2.7 μM for COX-1 and COX-2, respectively). (S)-Ketorolac is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac. Formulations containing ketorolac have been used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.
Chemische Eigenschaften
Off-White Solid
Verwenden
(S)-Ketorolac is the S-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
Definition
ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has S configuration. While (S)-ketorolac is a COX1 and COX2 inhibitor, both enantiomers exhibit analgesic effects. Racemic ketorolac, known s
mply as ketorolac, is used (mainly as the tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
(S)-Ketorolac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-Ketorolac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 62)Lieferanten
- Ketorolac S-IsoMer
- Ketorolac impurity 2/Ketorolac S-Isomer
- 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1S)-
- (S)-Ketorolac ISO 9001：2015 REACH
- Phosphorousacid,tris(1,5-dimethylethyl)ester
- 66635-92-5
- Aromatics
- Chiral Reagents
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
