1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
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- CAS-Nr.
- 3543-73-5
- Englisch Name:
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyma:
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- CBNumber:
- CB62485092
- Summenformel:
- C14H19N3O2
- Molgewicht:
- 261.32
- MOL-Datei:
- 3543-73-5.mol
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1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Eigenschaften
- Schmelzpunkt:
- 130-135°C
- Siedepunkt:
- 471.6±25.0 °C(Predicted)
- Dichte
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- L?slichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- pka
- 6.73±0.10(Predicted)
- Farbe
- Off-White to Pale Beige
- InChI
- InChI=1S/C14H19N3O2/c1-3-19-14(18)6-4-5-13-16-11-9-10(15)7-8-12(11)17(13)2/h7-9H,3-6,15H2,1-2H3
- InChIKey
- JUMGOLYNZBZPKE-UHFFFAOYSA-N
- SMILES
- C1(CCCC(OCC)=O)N(C)C2=CC=C(N)C=C2N=1
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Brown Solid
Verwenden
1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.
Synthese
In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 209)Lieferanten
- 5-AMINO-1-METHYL-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYL ESTER
- Ethyl-4-(5-aMino-1-Methy-1H-benzo[d] iMidazol-2-yl)butanoate
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- 4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acidethylester
- 5-amino-1-methyl-2-Benzimidazolebutyric acid ethyl ester
- 5-AMino-1-Methyl-
- 4-[5-AMino-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
- 1-Methyl-5-aMino-1H-benziMidazole-2-butanoic acid ethyl este
- BendaMustine hydrochloride interMediate
- 4-(5-aMino-1-Methyl-1H-benzoiMidazol-2-yl)-butyric acid ethyl esterCAS
- BendaMustine Dideschloroethyl Ethyl Ester
- ethyl 4-(5-aMino-1-Methyl-1H-1,3-benzodiazol-2-yl)butanoate
- ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate
- Bendamustine Intermediate
- Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
- Bendamustine hydrochloride Intermediates 2
- 5-(5-amino-1-methyl-2-benzimidazolyl)-1-methoxy-2-pentanone
- 4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate
- 1-Methyl-5-amino-1H-benzimidazole-2
- endamustine Dideschloroethyl Ethyl Ester
- 1H-Benzimidazole-2-butanoic acid, 5-amino-1-methyl-, ethyl ester
- Ethyl4-(5-amino-1-methyl-1Hbenzo[d]imidazole
-2-yl)butanoate
- ETHYL 4-(5-AMINO-1-METHYL-1HBENZIMIDAZOL-2-YL) BUTANOATE
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
- Bendamustine Hydrochloride Intermediate 3543-73-5 API Manufacturer
- Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- 3543-73-5
- Aromatics
- Heterocycles
- Intermediates
