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2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Struktur
321674-73-1
CAS-Nr.
321674-73-1
Englisch Name:
2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
Synonyma:
CS-1061;BIBR 1532;BIBR 1532, >=98%;BIBR 1532;BIBR-1532;Telomerase Inhibitor X;(E)-2-(3-phenylbut-2-enamido)benzoic acid;2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID;(E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid;2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid;2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
CBNumber:
CB62456353
Summenformel:
C21H17NO3
Molgewicht:
331.36
MOL-Datei:
321674-73-1.mol

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Eigenschaften

Schmelzpunkt:
>173oC (dec.)
Siedepunkt:
600.6±48.0 °C(Predicted)
Dichte
1.284
storage temp. 
Store at RT
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Sonicated)
Aggregatzustand
Solid
pka
3.46±0.36(Predicted)
Farbe
White to Off-White

Sicherheit

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells. Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.

Biologische Aktivit?t

Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 135)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 18750 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574
 info@chemia-pharm.com CHINA 311 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58

321674-73-1()Verwandte Suche:

  • 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID
  • BIBR 1532
  • 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
  • 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl]amino]benzoic acid
  • (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid
  • BIBR 1532, >=98%
  • BIBR 1532;BIBR-1532
  • CS-1061
  • (E)-2-(3-phenylbut-2-enamido)benzoic acid
  • Benzoic acid, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-
  • 2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID USP/EP/BP
  • Telomerase Inhibitor X
  • 2-[3-(NAPHTHALEN-2-YL)BUT-2-ENAMIDO]BENZOIC ACID
  • 321674-73-1
  • Inhibitors
  • API
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